1Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University GwanAk-Ro 1, GwanAk-Gu, Seoul 151-742, Korea.
2Department of Veterinary Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam.
Acta Vet Hung. 2021 Mar 15;69(1):94-99. doi: 10.1556/004.2021.00001.
Porcine epidemic diarrhoea virus (PEDV) is one of the major pathogens causing acute enteritis, which is characterised by vomiting and watery diarrhoea and commonly leads to high rates of mortality and morbidity in suckling piglets. Chitosan has been regarded as a promising natural disinfectant. In this study, the disinfectant effect and mammalian-cell toxicity of chitosan were evaluated against PEDV using Vero cells. A 0.01% solution of chitosan was determined to be an effective disinfectant. In addition, no evidence of toxicity was observed during the cell toxicity test; on the contrary, chitosan promoted cell proliferation. In conclusion, chitosan is a promising candidate for an effective and safe disinfectant against PEDV as well as other coronaviruses.
猪流行性腹泻病毒（PEDV）是引起急性肠炎的主要病原体之一，其特征是呕吐和水样腹泻，通常会导致哺乳仔猪的高死亡率和发病率。壳聚糖已被认为是一种很有前途的天然消毒剂。在这项研究中，使用 Vero 细胞评估了壳聚糖对 PEDV 的消毒效果和哺乳动物细胞毒性。确定 0.01%的壳聚糖溶液是一种有效的消毒剂。此外，在细胞毒性试验中没有观察到毒性证据；相反，壳聚糖促进了细胞增殖。总之，壳聚糖是一种有前途的候选物，可作为一种有效且安全的消毒剂，用于对抗 PEDV 以及其他冠状病毒。
