Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.
Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.
Semin Immunol. 2018 Feb;35:29-34. doi: 10.1016/j.smim.2018.02.001. Epub 2018 Feb 7.
Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia.
嗜碱性粒细胞、嗜酸性粒细胞和肥大细胞于 19 世纪末由保罗·埃尔利希首次发现。这些细胞在过敏性疾病的发病机制中和对抗寄生虫方面具有共同但非冗余的作用。然而，由于它们都能够产生各种各样的免疫介质并表达膜结合受体，因此它们能够与组织微环境中的免疫和非免疫成分相互作用，有助于调节组织稳态和免疫反应，同时参与进一步的组织失调转化为肿瘤。
