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[对狗脑进行电刺激所形成的条件反射泛化的机制]

[Mechanism of the generalization of a conditioned reflex elaborated to electrostimulation of the brain in dogs].

作者信息

Grigor'ian G A, Chilingarian L I

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 Jan-Feb;38(1):51-9.

PMID:3376568
Abstract

To study functional connections in the limbic system (LS), a model was used of instrumental alimentary CR, elaborated in response to low-frequency hippocampus electrostimulation with testing of its generalization within the LS. The dependence was established of the generalization on activation of corresponding pathways between the signal and tested brain structures, the activation of pathways was estimated by EPs recorded in limbic structures in response to hippocampus stimulation (during CR performance), or vice versa (in generalization trials). It turned out that for the appearance of CR generalization, two-way connections between signal and tested brain structures or connections only to the signal structure are more important. One-way connections from the signal structure to tested ones, judging by data, are not important for appearance of the CR generalization in used model of conditioning.

摘要

为了研究边缘系统(LS)中的功能连接,采用了一种工具性食物条件反射模型,该模型是针对低频海马体电刺激构建的,并在LS内对其泛化进行了测试。确定了泛化与信号和受试脑结构之间相应通路激活的依赖性,通过在海马体刺激时(在条件反射执行期间)记录在边缘结构中的诱发电位(EPs)来估计通路的激活情况,反之亦然(在泛化试验中)。结果表明,对于条件反射泛化的出现,信号与受试脑结构之间的双向连接或仅与信号结构的连接更为重要。根据数据判断,从信号结构到受试结构的单向连接对于所使用的条件反射模型中条件反射泛化的出现并不重要。

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