SRES Sanjivani College of Pharmaceutical Education and Research, Sahajanandnagar, Singnapur, Kopargaon, Ahmednagar, Maharashtra 423603, India; Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India.
SRES Sanjivani College of Pharmaceutical Education and Research, Sahajanandnagar, Singnapur, Kopargaon, Ahmednagar, Maharashtra 423603, India; The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India.
J Control Release. 2021 May 10;333:188-245. doi: 10.1016/j.jconrel.2021.03.021. Epub 2021 Mar 22.
Cancer being one of the most precarious and second most fatal diseases evokes opportunities for multimodal delivery platforms which will act synergistically for efficient cancer treatment. Multifunctional iron oxide magnetic nanoparticles (IONPs) are being studied for few decades and still attracting increasing attention for several biomedical applications owing to their multifunctional design and intrinsic magnetic properties that provide a multimodal theranostic platform for cancer therapy, monitoring and diagnosis. The review article aims to provide brief information on various surface chemistries involved in modulating IONPs properties to exhibit potential therapy in cancer treatment. The review addresses structural, magnetic, thermal and optical properties of IONPs which aids in the fabrication of efficient multimodal nanoplatform in cancer therapy. The review discussed the pharmacokinetics of IONPs and attributes influencing them. This review inculcates recent advancements in therapies, focused on tumor-microenvironment-responsive and targeted therapy along with their eminent role in cancer diagnosis. The concept of stimuli-responsive including endogenous, exogenous and dual/multi stimuli-based delivery platform demonstrated significantly enhanced anticancer therapy. Several therapeutic approaches viz. chemotherapy, radiotherapy, immunotherapy, hyperthermia, gene therapy, sonodynamic therapy, photothermal, photodynamic-based therapy along with biosensing and several toxicity aspects of IONPs have been addressed in this review for effective cancer treatment.
癌症是最危险和第二致命的疾病之一，为多模式递药平台提供了机会，这些平台将协同作用，实现有效的癌症治疗。多功能氧化铁磁性纳米粒子（IONPs）已经研究了几十年，由于其多功能设计和固有磁性，仍然吸引着越来越多的关注，为癌症治疗、监测和诊断提供了多模式治疗和诊断平台。本文旨在提供关于调节 IONPs 性质以显示癌症治疗潜在治疗效果的各种表面化学的简要信息。本文综述了 IONPs 的结构、磁性、热和光学性质，这些性质有助于制备有效的癌症治疗多模式纳米平台。本文讨论了 IONPs 的药代动力学及其影响因素。本文综述了最近在治疗方面的进展，重点介绍了肿瘤微环境响应和靶向治疗，以及它们在癌症诊断中的重要作用。刺激响应的概念，包括内源性、外源性和双/多刺激递药平台，显著增强了抗癌治疗效果。本文综述了几种治疗方法，如化疗、放疗、免疫疗法、热疗、基因疗法、声动力学疗法、光热疗法、光动力疗法以及生物传感和 IONPs 的几种毒性方面，以实现有效的癌症治疗。
