Department of Colorectal Surgery, First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
Department of Neurosurgery, First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
Front Endocrinol (Lausanne). 2024 Aug 29;15:1445934. doi: 10.3389/fendo.2024.1445934. eCollection 2024.
Diabetes is a significant global health concern, with a growing prevalence in Japan. Individuals with normal body mass index who are metabolically unhealthy exhibit an elevated risk of diabetes onset. Investigating the relationship between Metabolically Unhealthy Normal-weight (MUNW) status and the risk of diabetes in non-diabetic individual is vital for implementing early preventive strategies.
Using data from the NAGALA cohort, This study categorized 8,194 Japanese adults based on the score of metabolic syndrome (MetS) components they possessed. Cox proportional hazards regression models and multivariate logistic regression were used to assess the relationship between MUNW and the risk of developing diabetes, with analyses stratified by age and sex.
During an average follow-up of 7.19 years, 123 participants (1.5%) were diagnosed with diabetes. Among the participants, 766 (9.35%) were classified as MUNW, and 157 (1.92%) as having MetS. Compared to those with no MetS components, individuals with 1, 2, and ≥3 MetS components had progressively higher adjusted hazard ratios (HRs) for developing diabetes, at 4.56, 8.79, and 25.16, respectively. Further stratified analysis revealed that men aged ≤40 years had the highest risk of developing diabetes. For men, the adjusted HRs for having 1, 2, and ≥3 MetS components were 5.61, 7.80, and 28.59, respectively, and for participants aged ≤40 years, the HRs were 12.31, 25.57, and 129.82, respectively.
The prevalence of MUNW in non-diabetic individuals in Japan is 9.35%. The score of MetS components was positively correlated with the risk of diabetes. Early intervention and lifestyle modifications are crucial, especially for MUNW individuals and notably young Japanese men aged ≤40 years, for the prevention and management of diabetes.
糖尿病是一个严重的全球健康问题，在日本的发病率也在不断上升。身体质量指数正常但代谢不健康的个体患糖尿病的风险较高。研究代谢不健康的正常体重（MUNW）状态与非糖尿病个体发生糖尿病的风险之间的关系对于实施早期预防策略至关重要。
本研究使用 NAGALA 队列的数据，根据代谢综合征（MetS）成分评分将 8194 名日本成年人分为不同组别。采用 Cox 比例风险回归模型和多变量逻辑回归模型评估 MUNW 与发生糖尿病风险之间的关系，并按年龄和性别进行分层分析。
在平均 7.19 年的随访期间，123 名参与者（1.5%）被诊断患有糖尿病。在参与者中，766 名（9.35%）被归类为 MUNW，157 名（1.92%）患有 MetS。与没有 MetS 成分的参与者相比，患有 1、2 和≥3 个 MetS 成分的个体发生糖尿病的调整后危险比（HR）分别为 4.56、8.79 和 25.16。进一步的分层分析显示，年龄≤40 岁的男性发生糖尿病的风险最高。对于男性，患有 1、2 和≥3 个 MetS 成分的调整后 HR 分别为 5.61、7.80 和 28.59，而对于年龄≤40 岁的参与者，HR 分别为 12.31、25.57 和 129.82。
日本非糖尿病个体中 MUNW 的患病率为 9.35%。MetS 成分评分与糖尿病风险呈正相关。对于 MUNW 个体和年龄≤40 岁的年轻日本男性，早期干预和生活方式改变至关重要，以预防和管理糖尿病。
