突尼斯一所大学医院布鲁氏菌病的临床和实验室特征。
Clinical and laboratory features of brucellosis in a university hospital in Tunisia.
机构信息
Microbiology department, Rabta Hospital, 1007 Tunis, Tunisia.
Infectious diseases department, Rabta Hospital, 1007 Tunis, Tunisia.
出版信息
Infect Dis Now. 2021 Sep;51(6):547-551. doi: 10.1016/j.idnow.2021.03.005. Epub 2021 Mar 22.
AIM OF THE STUDY
The increase in the number of brucellosis cases between 2014 and 2017 (14 and 90 cases respectively) led us to study the biological and clinical-epidemiologic characteristics patients hospitalized in Rabta hospital of Tunis.
MATERIAL AND METHODS
This retrospective study was conducted in Rabta Hospital in Tunis between 2016 and 2017. It includes 131 patients who had a positive bacteriological diagnosis of Brucella between 2016 and 2017. Diagnosis of brucellosis was made in blood culture by using Bactalert (Biomerieux®). Identification of Brucella was realized by Gram staining, catalase, oxydase. Serological diagnosis was made by testing sera for brucellosis agglutinins with Rose Bengale and the standard agglutination test. The collected data were analyzed by SPSS softcare version 24.
RESULTS
The prevalence of Brucellosis in Rabta hospital increases from 14 cases in 2014 to 90 cases in 2017. The mean age was 45 years and ages range from 16 to 84 years. Rural origin was found in 75 cases (68%). Ninety-seven patients (89%) were hospitalized in the infectious diseases department. The average length of hospitalization was 17.25 days. Fifty-seven patients (52%) had a history of consuming unpasteurized dairy products and 45 (41%) were farmers. Fever was the predominant symptom in 104 cases (95%). Osteoarticular involvement is the most common complication of brucellosis and it occurred in 28% of patients. Blood cultures were 73 cases and 42 (57%) were positive for Brucella spp. Rose Bengale was positive in 100% of cases. High titles of the standard agglutination test (superior to 1/1280) were noted in 24 cases (22%).
CONCLUSION
Brucellosis is still endemic In Tunisia. Contact with domestic animals and consumption of raw milk and milk products seems to be the major mode of transmission. Control of animal infection by vaccination, occupational and personal hygiene, farm sanitation and preventive measures can reduce disease incidence.
研究目的
2014 年至 2017 年（分别为 14 例和 90 例）布鲁氏菌病病例数的增加促使我们研究突尼斯拉巴特医院住院患者的生物学和临床流行病学特征。
材料和方法
本回顾性研究于 2016 年至 2017 年在突尼斯拉巴特医院进行。它包括 2016 年至 2017 年期间血培养阳性的 131 例布鲁氏菌患者。布鲁氏菌病的诊断通过 Bactalert（Biomerieux®）在血液培养中进行。革兰氏染色、触酶、氧化酶用于鉴定布鲁氏菌。血清学诊断通过用 Rose Bengal 和标准凝集试验检测血清中的布鲁氏菌凝集素来进行。收集的数据通过 SPSS softcare 版本 24 进行分析。
结果
拉巴特医院的布鲁氏菌病患病率从 2014 年的 14 例增加到 2017 年的 90 例。平均年龄为 45 岁，年龄范围为 16 至 84 岁。75 例（68%）为农村来源。97 例（89%）患者住院于传染病科。平均住院时间为 17.25 天。57 例（52%）有食用未经巴氏消毒的乳制品史，45 例（41%）为农民。发热是 104 例（95%）患者的主要症状。骨关节受累是布鲁氏菌病最常见的并发症，发生率为 28%。血培养 73 例，42 例（57%）布鲁氏菌阳性。Rose Bengale 试验均为阳性（100%）。24 例（22%）标准凝集试验滴度较高（大于 1/1280）。
结论
布鲁氏菌病在突尼斯仍呈地方性流行。接触动物和食用生奶及奶制品似乎是主要的传播途径。通过疫苗接种、职业和个人卫生、农场卫生和预防措施控制动物感染，可以降低疾病发病率。
Zotero 插件