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对“大规模 GWAS 揭示了同性性行为遗传结构的见解”的评论的回应。

Response to Comment on "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior".

机构信息

Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

出版信息

Science. 2021 Mar 26;371(6536). doi: 10.1126/science.aba5693.

DOI:10.1126/science.aba5693
PMID:33766859
Abstract

Hamer argue that the variable "ever versus never had a same-sex partner" does not capture the complexity of human sexuality. We agree and said so in our paper. But Hamer neglect to mention that we also reported follow-up analyses showing substantial overlap of the genetic influences on our main variable and on more nuanced measures of sexual behavior, attraction, and identity.

摘要

哈默认为“是否曾有过同性伴侣”这个变量并不能捕捉到人类性行为的复杂性。我们同意这一观点，并在我们的论文中也提到了这一点。但哈默没有提到，我们还报告了后续分析结果，这些结果表明，我们主要变量的遗传影响与性行为、吸引力和身份认同的更微妙的衡量标准之间存在实质性的重叠。

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