Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, 2525 West End Ave., Suite 400, Nashville, TN, 37203, USA.
College of Arts and Sciences, Vanderbilt University, Nashville, TN, USA.
Behav Genet. 2022 Sep;52(4-5):246-267. doi: 10.1007/s10519-022-10105-y. Epub 2022 May 26.
We conducted in-depth, semi-structured interviews with LGBTQ+-identified individuals (n = 31) to explore the range of LGBTQ+ perspectives on genomic research using either sexual orientation or gender identity (SOGI) data. Most interviewees presumed that research would confirm genetic contributions to sexual orientation and gender identity. Primary hopes for such confirmation included validating LGBTQ+ identities, improved access to and quality of healthcare and other resources, and increased acceptance in familial, socio-cultural, and political environments. Areas of concern included threats of pathologizing and medicalizing LGBTQ+ identities and experiences, undermining reproductive rights, gatekeeping of health or social systems, and malicious testing or misuse of genetic results, particularly for LGBTQ+ youth. Overall, interviewees were divided on the acceptability of genomic research investigating genetic contributions to sexual orientation and gender identity. Participants emphasized researchers' ethical obligations to LGBTQ+ individuals and endorsed engagement with LGBTQ+ communities throughout all aspects of genomic research using SOGI data.
我们对 31 名 LGBTQ+ 个体（n=31）进行了深入的半结构化访谈，以探讨使用性取向或性别认同（SOGI）数据的 LGBTQ+ 对基因组研究的各种观点。大多数受访者推测研究将证实性取向和性别认同的遗传贡献。对此类证实的主要期望包括验证 LGBTQ+身份、改善获取和医疗保健及其他资源的质量，以及在家庭、社会文化和政治环境中提高接受度。关注的领域包括将 LGBTQ+身份和经历病理化和医学化的威胁、破坏生殖权利、对健康或社会系统的把关，以及恶意测试或滥用遗传结果，特别是对 LGBTQ+青年。总体而言，受访者对调查性取向和性别认同遗传贡献的基因组研究的可接受性存在分歧。参与者强调了研究人员对 LGBTQ+个体的道德义务，并支持在使用 SOGI 数据进行基因组研究的所有方面与 LGBTQ+社区进行接触。
