蛋白质基因组学推动精准肿瘤学的治疗假说生成。
Proteogenomics drives therapeutic hypothesis generation for precision oncology.
机构信息
Lester and Sue Smith Breast Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA.
出版信息
Br J Cancer. 2021 Jul;125(1):1-3. doi: 10.1038/s41416-021-01346-5. Epub 2021 Mar 25.
Abstract
Precision oncology has largely been driven by genomic profiling, but success so far has been limited. By combining genomic and proteomic analyses of tumours, proteogenomics holds promise in providing deeper mechanistic insights and generating therapeutic hypotheses to better match patients to targeted treatments than analysing each 'ome in isolation.
摘要
精准肿瘤学在很大程度上受到基因组分析的推动，但迄今为止，其成功是有限的。通过对肿瘤进行基因组和蛋白质组分析的结合，蛋白质基因组学有望提供更深入的机制见解，并生成治疗假设，以更好地将患者与靶向治疗相匹配，而不是单独分析每个“组学”。
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