电化学C(sp)–H氟化反应
Electrochemical C(sp)-H Fluorination.
作者信息
Takahira Yusuke, Chen Miao, Kawamata Yu, Mykhailiuk Pavel, Nakamura Hugh, Peters Byron K, Reisberg Solomon H, Li Chao, Chen Longrui, Hoshikawa Tamaki, Shibuguchi Tomoyuki, Baran Phil S
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv (Ukraine) and Taras Shevchenko National University of Kyiv; Chemistry Department; Volodymyrska 64, 01601 Kyiv (Ukraine).
出版信息
Synlett. 2019 Jun;30(10):1178-1182. doi: 10.1055/s-0037-1611737. Epub 2019 Mar 1.
Abstract
A simple and robust method for electrochemical alkyl C-H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated C-H bonds were converted to their C-F congeners. The scalability of the reaction was also demonstrated with a 100 gram preparation of fluorovaline.
摘要
本文提出了一种简单且稳健的电化学烷基C-H氟化方法。使用一种简单的硝酸盐添加剂、一种广泛可得的氟源（Selectfluor）和碳基电极，多种活化和未活化的C-H键被转化为其C-F同类物。通过制备100克氟缬氨酸也证明了该反应的可扩展性。
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