Takeuchi Y, Fujiwara K, Ishimura K, Yoshioka H, Sawada T
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Acta Neuropathol. 1988;75(6):541-6. doi: 10.1007/BF00686197.
Changes occurring in serotonin neurons during hyperthermia-induced convulsions were examined by means of a modified immunohistochemical method. All mice (8-12 weeks of age) exposed to the temperature of 50 degrees C had convulsions, showing a generalized tonic and/or clonic pattern. Immediately after the convulsions, the animals were perfused transcardially with a fixative. A significant reduction in serotonin immunoreactivity was observed in the neostriatum (caudate-putamen complex) of the mice which had hyperthermia-induced seizures, while the serotonin immunoreactivity remained unchanged in the neocortex and paleostriatum. These results suggest that serotonin may be an important mediator in the mechanism of hyperthermia-induced convulsions or that the susceptibility of serotonin neurons to a convulsive state is greatest in the neostriatum.
采用改良免疫组织化学方法，研究了高温诱导惊厥过程中5-羟色胺能神经元的变化。所有暴露于50℃的小鼠（8-12周龄）均出现惊厥，表现为全身性强直和/或阵挛性发作。惊厥发作后，立即经心脏灌注固定液处死动物。高温诱导惊厥的小鼠，其新纹状体（尾状核-壳核复合体）中5-羟色胺免疫反应性显著降低，而新皮质和旧纹状体中5-羟色胺免疫反应性保持不变。这些结果表明，5-羟色胺可能是高温诱导惊厥机制中的重要介质，或者5-羟色胺能神经元对惊厥状态的易感性在新纹状体中最高。
