Cvejić V, Mićić D V, Djuricić B M, Mrsulja B J, Mrsulja B B
Acta Neuropathol. 1980;51(1):71-7. doi: 10.1007/BF00688852.
The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries of occlusion for 15 min and reflow for 7 days. Disorders of monoamine metabolism was found in ischemic brain which persisted during the long-term post-ischemia. A rebound increase of norepinephrine and serotonin appeared in early stages (up to 1 h) of post-ischemia both in cerebral cortex and basal ganglia; a rebound increase of dopamine as found only in cerebral cortex. Thereafter, the serotonin level ws enhanced over the control level during the whole post-ischemic period whereas the levels of catecholamines were reduced particularly in basal ganglia. With respect to monoamine content and activities of monoamine degraded enzymes an oscillatory behavior was observed in the post-ischemia. Disorder of the monoamine metabolism found during post-ischemic period possibly contributes to neurological dysfunction after an ischemic insult.
在蒙古沙鼠（长爪沙鼠）中评估了缺血后对大脑皮质和基底神经节单胺水平、单胺氧化酶（MAO A和B）以及儿茶酚-O-甲基转移酶（COMT）活性的影响，这些沙鼠双侧颈总动脉闭塞15分钟并再灌注7天。发现在缺血性脑中存在单胺代谢紊乱，且在缺血后长期持续存在。在缺血后早期阶段（长达1小时），大脑皮质和基底神经节中的去甲肾上腺素和5-羟色胺均出现反弹性增加；多巴胺的反弹性增加仅在大脑皮质中发现。此后，在整个缺血后时期，5-羟色胺水平高于对照水平，而儿茶酚胺水平降低，尤其是在基底神经节中。关于单胺含量和单胺降解酶的活性，在缺血后观察到振荡行为。缺血后时期发现的单胺代谢紊乱可能导致缺血性损伤后的神经功能障碍。
