• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在放疗后的长期前列腺癌适应性过程中，这些长链非编码RNA（lncRNAs）被上调。

The lncRNAs and are upregulated in long-term prostate cancer adaptation after radiotherapy.

作者信息

Eke Iris, Bylicky Michelle A, Sandfort Veit, Chopra Sunita, Martello Shannon, Graves Edward E, Coleman C Norman, Aryankalayil Molykutty J

机构信息

Department of Radiation Oncology, Stanford University School of Medicine, Center for Clinical Sciences Research (CCSR), Stanford, CA 94305, USA.

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Mol Ther Nucleic Acids. 2021 Feb 24;24:175-187. doi: 10.1016/j.omtn.2021.02.024. eCollection 2021 Jun 4.

DOI:10.1016/j.omtn.2021.02.024
PMID:33767914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7960506/
Abstract

Long non-coding RNAs (lncRNAs) have been shown to impact important biological functions such as proliferation, survival, and genomic stability. To analyze radiation-induced lncRNA expression in human tumors, we irradiated prostate cancer cells with a single dose of 10 Gy or a multifractionated radiotherapeutic regimen of 10 fractions with a dose of 1 Gy (10 × 1 Gy) during 5 days. We found a stable upregulation of the lncRNA and at 2 months after radiotherapy that was more pronounced after single-dose irradiation. Analysis of the The Cancer Genome Atlas (TCGA) and The Atlas of Non-coding RNAs in Cancer (TANRIC) databases showed that high expression of these two lncRNAs may be a potential negative prognostic marker for overall survival of prostate cancer patients. Knockdown of and in long-term survivors decreased survival after re-irradiation and affected DNA double-strand break repair. Mechanistically, both lncRNAs showed an interdependent expression and regulated expression of the DNA repair proteins CtIP () and XPC as well as the microRNA . Identifying long-term tumor adaptation mechanisms can lead to the discovery of new molecular targets, in effect opening up new research directions and improving multimodal radiation oncologic treatment.

摘要

长链非编码RNA（lncRNAs）已被证明会影响重要的生物学功能，如增殖、存活和基因组稳定性。为了分析人类肿瘤中辐射诱导的lncRNA表达，我们用10 Gy的单剂量或在5天内给予1 Gy（10×1 Gy）的10次分割放射治疗方案照射前列腺癌细胞。我们发现放疗后2个月lncRNA 和 稳定上调，单剂量照射后更为明显。对癌症基因组图谱（TCGA）和癌症非编码RNA图谱（TANRIC）数据库的分析表明，这两种lncRNA的高表达可能是前列腺癌患者总生存的潜在负面预后标志物。在长期存活者中敲低 和 会降低再次照射后的存活率，并影响DNA双链断裂修复。从机制上讲，这两种lncRNA都表现出相互依赖的表达，并调节DNA修复蛋白CtIP（ ）和XPC以及微小RNA 的表达。确定长期肿瘤适应机制可导致发现新的分子靶点，实际上开辟新的研究方向并改善多模式放射肿瘤治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/e8bbf27e5fcb/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/1a7b0200400e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/36a7c53d0222/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/1f656b402f52/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/ecc2366068f2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/1bb207f43078/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/5bd5f7803b84/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/8c4d47483d9b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/e8bbf27e5fcb/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/1a7b0200400e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/36a7c53d0222/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/1f656b402f52/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/ecc2366068f2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/1bb207f43078/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/5bd5f7803b84/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/8c4d47483d9b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/7960506/e8bbf27e5fcb/gr7.jpg

相似文献

1
The lncRNAs and are upregulated in long-term prostate cancer adaptation after radiotherapy.在放疗后的长期前列腺癌适应性过程中，这些长链非编码RNA（lncRNAs）被上调。
Mol Ther Nucleic Acids. 2021 Feb 24;24:175-187. doi: 10.1016/j.omtn.2021.02.024. eCollection 2021 Jun 4.
2
Expression of the Long Intergenic Non-Protein Coding RNA 665 (LINC00665) Gene and the Cell Cycle in Hepatocellular Carcinoma Using The Cancer Genome Atlas, the Gene Expression Omnibus, and Quantitative Real-Time Polymerase Chain Reaction.利用癌症基因组图谱、基因表达综合数据库和实时定量聚合酶链反应技术研究长链非编码 RNA 665（LINC00665）基因在肝癌中的表达与细胞周期。
Med Sci Monit. 2018 May 5;24:2786-2808. doi: 10.12659/MSM.907389.
3
The Emerging Roles of LINC00665 in Human Cancers.LINC00665在人类癌症中的新兴作用
Front Cell Dev Biol. 2022 Mar 9;10:839177. doi: 10.3389/fcell.2022.839177. eCollection 2022.
4
Downregulation of LINC00665 confers decreased cell proliferation and invasion via the miR-138-5p/E2F3 signaling pathway in NSCLC.下调 LINC00665 通过 miR-138-5p/E2F3 信号通路抑制非小细胞肺癌细胞的增殖和侵袭。
Biomed Pharmacother. 2020 Jul;127:110214. doi: 10.1016/j.biopha.2020.110214. Epub 2020 May 11.
5
Radiotherapy alters expression of molecular targets in prostate cancer in a fractionation- and time-dependent manner.放疗以时-量依赖的方式改变前列腺癌中分子靶点的表达。
Sci Rep. 2022 Mar 3;12(1):3500. doi: 10.1038/s41598-022-07394-y.
6
Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls.鉴定儿童癌症长期幸存者和成癌-free对照的成纤维细胞中参与对电离辐射反应的长链非编码RNA。
Front Oncol. 2023 Apr 27;13:1158176. doi: 10.3389/fonc.2023.1158176. eCollection 2023.
7
LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity.LINC00261在胰腺癌亚型中差异表达并调控上皮细胞特性。
Cancers (Basel). 2020 May 13;12(5):1227. doi: 10.3390/cancers12051227.
8
Heavy-Ion Carbon Radiation Regulates Long Non-Coding RNAs in Cervical Cancer HeLa Cells.重离子碳辐射调控宫颈癌HeLa细胞中的长链非编码RNA
J Cancer. 2019 Aug 28;10(21):5022-5030. doi: 10.7150/jca.30846. eCollection 2019.
9
Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection.解析口腔癌lncRNA组：鉴定与恶性进展和人乳头瘤病毒感染相关的新型lncRNA
Oral Oncol. 2016 Aug;59:58-66. doi: 10.1016/j.oraloncology.2016.05.014.
10
LINC00261 inhibits progression of pancreatic cancer by down-regulating miR-23a-3p.LINC00261 通过下调 miR-23a-3p 抑制胰腺癌的进展。
Arch Biochem Biophys. 2020 Aug 15;689:108469. doi: 10.1016/j.abb.2020.108469. Epub 2020 Jun 24.

引用本文的文献

1
Long non-coding RNAs: regulators of autophagy and potential biomarkers in therapy resistance and urological cancers.长链非编码RNA：自噬的调节因子以及治疗耐药性和泌尿系统癌症中的潜在生物标志物。
Front Pharmacol. 2024 Oct 24;15:1442227. doi: 10.3389/fphar.2024.1442227. eCollection 2024.
2
Contemporary Update on Clinical and Experimental Prostate Cancer Biomarkers: A Multi-Omics-Focused Approach to Detection and Risk Stratification.前列腺癌临床与实验生物标志物的当代进展：一种聚焦多组学的检测与风险分层方法
Biology (Basel). 2024 Sep 25;13(10):762. doi: 10.3390/biology13100762.
3
Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention.

本文引用的文献

1
LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis.长链非编码 RNA SNHG7 通过调控 miR-329-3p/MYO10 轴增强顺铂诱导的自噬从而增强神经母细胞瘤的化疗耐药性。
Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):3805-3817. doi: 10.26355/eurrev_202004_20847.
2
LncRNA LINC00665 Promotes Prostate Cancer Progression via miR-1224-5p/SND1 Axis.长链非编码RNA LINC00665通过miR-1224-5p/SND1轴促进前列腺癌进展。
Onco Targets Ther. 2020 Mar 26;13:2527-2535. doi: 10.2147/OTT.S241578. eCollection 2020.
3
Long non-coding RNA LINC00665 promotes metastasis of breast cancer cells by triggering EMT.
基于多组学的 FaDu 异种移植瘤小鼠在放射和 HSP90 抑制剂联合治疗后的分子图谱，鉴定了适应性耐药的靶标和治疗干预靶点。
Mol Cancer Ther. 2024 Apr 2;23(4):577-588. doi: 10.1158/1535-7163.MCT-23-0796.
4
Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers.解析 lncRNAs 的调控图谱作为胃癌和结直肠癌潜在的诊断和预后生物标志物。
Clin Exp Med. 2024 Jan 31;24(1):29. doi: 10.1007/s10238-023-01260-5.
5
Emerging evidence for adapting radiotherapy to immunotherapy.新兴证据表明放疗与免疫疗法相结合具有优势。
Nat Rev Clin Oncol. 2023 Aug;20(8):543-557. doi: 10.1038/s41571-023-00782-x. Epub 2023 Jun 6.
6
Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis.LINC00665 在癌症中的预后和临床病理价值：系统评价和中国人群的荟萃分析。
Clin Exp Med. 2023 Sep;23(5):1475-1487. doi: 10.1007/s10238-022-00912-2. Epub 2022 Oct 11.
7
Current Status and Prospects of Clinical Treatment of Osteosarcoma.骨肉瘤的临床治疗现状及展望。
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221124696. doi: 10.1177/15330338221124696.
8
Prostate cancer in omics era.组学时代的前列腺癌
Cancer Cell Int. 2022 Sep 5;22(1):274. doi: 10.1186/s12935-022-02691-y.
9
Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention.长链非编码 RNA 在前列腺癌中的分子特征：干预途径和治疗靶点的关注。
J Exp Clin Cancer Res. 2022 Jul 1;41(1):214. doi: 10.1186/s13046-022-02406-1.
10
The Biological and Molecular Function of LINC00665 in Human Cancers.LINC00665在人类癌症中的生物学和分子功能
Front Oncol. 2022 May 19;12:886034. doi: 10.3389/fonc.2022.886034. eCollection 2022.
长非编码 RNA LINC00665 通过触发 EMT 促进乳腺癌细胞的转移。
Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):3097-3104. doi: 10.26355/eurrev_202003_20674.
4
A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions.长链非编码 RNA-SWI/SNF 复合物相互作用控制特定启动子区域的转录激活。
Nat Commun. 2020 Feb 18;11(1):936. doi: 10.1038/s41467-020-14623-3.
5
53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy.53BP1/RIF1 信号通路促进多次分割放疗后细胞的存活。
Nucleic Acids Res. 2020 Feb 20;48(3):1314-1326. doi: 10.1093/nar/gkz1139.
6
Up-regulated LINC00261 predicts a poor prognosis and promotes a metastasis by EMT process in cholangiocarcinoma.上调的LINC00261预示着胆管癌预后不良，并通过上皮-间质转化过程促进转移。
Pathol Res Pract. 2020 Jan;216(1):152733. doi: 10.1016/j.prp.2019.152733. Epub 2019 Nov 11.
7
RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.RBBP8/CtIP 通过与 CtBP 和 BRCA1 在胃癌中相互作用来抑制 P21 的表达。
Oncogene. 2020 Feb;39(6):1273-1289. doi: 10.1038/s41388-019-1060-7. Epub 2019 Oct 21.
8
miRDB: an online database for prediction of functional microRNA targets.miRDB：一个用于预测功能 microRNA 靶标的在线数据库。
Nucleic Acids Res. 2020 Jan 8;48(D1):D127-D131. doi: 10.1093/nar/gkz757.
9
Long Non-Coding RNA in the Pathogenesis of Cancers.长链非编码 RNA 在癌症发病机制中的作用。
Cells. 2019 Sep 1;8(9):1015. doi: 10.3390/cells8091015.
10
LncRNA TP73-AS1 is a novel regulator in cervical cancer via miR-329-3p/ARF1 axis.长链非编码 RNA TP73-AS1 通过 miR-329-3p/ARF1 轴调控宫颈癌的发生。
J Cell Biochem. 2020 Jan;121(1):344-352. doi: 10.1002/jcb.29181. Epub 2019 Jun 24.