Zhang Cheng, Xu Shu-Ning, Li Ke, Chen Jing-Hong, Li Qun, Liu Ying
Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
Front Oncol. 2022 May 19;12:886034. doi: 10.3389/fonc.2022.886034. eCollection 2022.
Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and are implicated in the development of human cancers, without protein-coding function. Mounting evidence indicates that cancer initiation and progression are triggered by lncRNA dysregulation. Recently, a growing number of studies have found that LINC00665, a long intergenic non-protein coding RNA, may be associated with various cancers, including gastrointestinal tumors, gynecological tumors, and respiratory neoplasms. LINC00665 was reported to be significantly dysregulated in cancers and has an important clinical association. It participates in cell proliferation, migration, invasion, and apoptosis through different biological pathways. In this review, we summarize the current findings on LINC00665, including its biological roles and molecular mechanisms in various cancers. LINC00665 may be a potential prognostic biomarker and novel therapeutic target for cancers.
长链非编码RNA（lncRNAs）长度超过200个核苷酸，在人类癌症发生发展过程中发挥作用，不具备蛋白质编码功能。越来越多的证据表明，lncRNA失调会引发癌症的起始和进展。最近，越来越多的研究发现，长链基因间非蛋白质编码RNA LINC00665可能与多种癌症相关，包括胃肠道肿瘤、妇科肿瘤和呼吸道肿瘤。据报道，LINC00665在癌症中显著失调，具有重要的临床关联。它通过不同的生物学途径参与细胞增殖、迁移、侵袭和凋亡。在这篇综述中，我们总结了目前关于LINC00665的研究结果，包括其在各种癌症中的生物学作用和分子机制。LINC00665可能是一种潜在的癌症预后生物标志物和新型治疗靶点。
