Zhu Jing, Zhang Yirao, Chen Xuyu, Bian Yibo, Li Juan, Wang Keming
Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Front Cell Dev Biol. 2022 Mar 9;10:839177. doi: 10.3389/fcell.2022.839177. eCollection 2022.
Long non-coding RNAs (lncRNAs) are non-coding RNAs that have more than 200 nucleotides and can participate in the regulation of gene expression in various ways. An increasing number of studies have shown that the dysregulated expression of lncRNAs is related to the occurrence and progression of human cancers. LINC00665 is a novel lncRNA, which is abnormally expressed in various human cancers, such as lung cancer, breast cancer, prostate cancer, and glioma. LINC00665 functions in many biological processes of tumor cells, such as cell proliferation, migration, invasion, angiogenesis, and metabolism, and is related to the clinicopathological characteristics of cancer patients. LINC00665 can play biological functions as a ceRNA, directly binding and interacting with proteins, and as an upstream molecule regulating multiple signaling pathways. In this review, we comprehensively summarize the expression level, function, and molecular mechanisms of LINC00665 in different human cancers and emphasize that LINC00665 is a promising new diagnostic, prognostic biomarker, and therapeutic target.
长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸的非编码RNA，能够以多种方式参与基因表达的调控。越来越多的研究表明，lncRNAs表达失调与人类癌症的发生和进展相关。LINC00665是一种新型lncRNA，在多种人类癌症中异常表达，如肺癌、乳腺癌、前列腺癌和神经胶质瘤。LINC00665在肿瘤细胞的许多生物学过程中发挥作用，如细胞增殖、迁移、侵袭、血管生成和代谢，并且与癌症患者的临床病理特征相关。LINC00665可以作为竞争性内源RNA（ceRNA）发挥生物学功能，直接与蛋白质结合并相互作用，还可以作为调节多种信号通路的上游分子。在本综述中，我们全面总结了LINC00665在不同人类癌症中的表达水平、功能和分子机制，并强调LINC00665是一种有前景的新型诊断、预后生物标志物和治疗靶点。
