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一名感染严重急性呼吸综合征冠状病毒2的患者出现急性肾衰竭

Acute Renal Failure in a Patient With Severe Acute Respiratory Syndrome Coronavirus 2.

作者信息

Ayad Sarah, Elkattawy Sherif, Ejikeme Chidinma, Al-Nasseri Abraheim, Reddy Aravinda

机构信息

Internal Medicine, Rutgers-New Jersey Medical School / Trinitas Regional Medical Center, Elizabeth, USA.

Internal Medicine, New Jersey Medical School-Rutgers / Trinitas Regional Medical Center, Elizabeth, USA.

出版信息

Cureus. 2021 Feb 17;13(2):e13406. doi: 10.7759/cureus.13406.

DOI:10.7759/cureus.13406
PMID:33767927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7983180/
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious viral pathogen with high morbidity and mortality rate. The infection affects multiple organ systems leading to systemic organ failure. There is an increased incidence of acute kidney injury (AKI) in patients who become critically ill. In the critical care setting, the incidence of AKI has been variable amongst different studies. Patients with acute kidney injury who progress to renal replacement therapy are associated with worse outcomes. We describe a case of a 42-year-old male who presented with hypoxemic respiratory failure secondary to SARS-CoV-2 associated pneumonia. The patient was initially managed with the nasal cannula and then required high flow nasal cannula with worsening hypoxemic respiratory failure, requiring invasive mechanical ventilation. On top of worsening respiratory status, the patient developed new onset renal failure requiring hemodialysis.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是一种具有高传染性的病毒病原体,发病率和死亡率都很高。该感染会影响多个器官系统,导致全身器官衰竭。重症患者急性肾损伤(AKI)的发病率有所增加。在重症监护环境中,不同研究中AKI的发病率各不相同。进展为肾脏替代治疗的急性肾损伤患者预后较差。我们描述了一例42岁男性病例,该患者因SARS-CoV-2相关性肺炎出现低氧性呼吸衰竭。患者最初采用鼻导管吸氧治疗,随后因低氧性呼吸衰竭加重而需要高流量鼻导管吸氧,最终需要有创机械通气。除了呼吸状况恶化外,患者还出现了新发肾衰竭,需要进行血液透析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb94/7983180/cd59a49077a8/cureus-0013-00000013406-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb94/7983180/03103588eac2/cureus-0013-00000013406-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb94/7983180/cd59a49077a8/cureus-0013-00000013406-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb94/7983180/03103588eac2/cureus-0013-00000013406-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb94/7983180/cd59a49077a8/cureus-0013-00000013406-i02.jpg

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Kidney360. 2020 May 13;1(7):614-622. doi: 10.34067/KID.0002652020. eCollection 2020 Jul 30.
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COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.COVID-19 相关急性肾损伤:第 25 届急性疾病质量倡议(ADQI)工作组的共识报告。
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Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19.肾素-血管紧张素-醛固酮系统的激活与 COVID-19 中的急性肾损伤有关。
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