不良反应发生时游离伊曲康唑浓度显著升高：一例病例报告。
Significant elevation of free itraconazole concentration at onset of adverse effects: A case report.
作者信息
Tanaka Ryota, Suzuki Yosuke, Matsumoto Hiroyuki, Yamasue Mari, Umeki Kenji, Hashinaga Kazuhiko, Tatsuta Ryosuke, Hiramatsu Kazufumi, Kamei Katsuhiko, Kadota Jun-Ichi, Itoh Hiroki
机构信息
Department of Clinical Pharmacy Oita University Hospital Yufu-shi Japan.
Department of Respiratory Medicine and Infectious Diseases Oita University Faculty of Medicine Yufu-shi Japan.
出版信息
Clin Case Rep. 2021 Jan 14;9(3):1187-1192. doi: 10.1002/ccr3.3726. eCollection 2021 Mar.
Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects.
尽管因不良反应停用伊曲康唑后总浓度几乎没有变化，但游离伊曲康唑和羟基伊曲康唑的浓度显著升高。游离伊曲康唑浓度升高可能与不良反应的发生存在因果关系。
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