MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. China.
Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, 350108, P. R. China.
Angew Chem Int Ed Engl. 2021 May 25;60(22):12560-12568. doi: 10.1002/anie.202102893. Epub 2021 Apr 28.
Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage of (ca. 100/75/50/25 %) are presented. The internal nanogap between the partial Au shell and core caused asymmetric optical behavior; tunability depends on the degree of Au shell coverage and structural asymmetry. The shell-to-shell or core-to-core JAuNNDs(50 %) were self-assembled from amphiphilic JAuNNPs(50 %) by tuning the hydrophilic and hydrophobic polymer brushes on the Au core or shell. The positions of electromagnetic field enhancement of JAuNNDs varied with geometrical configurations because of hybridized plasmonic coupling effects. Furthermore, DNA linkers were utilized to form JAuNND (50 %). By combining with Raman molecules, ratiometric SERS signals could be generated, enabling JAuNND (50 %) to image the distribution of miR-21 in living cells and tumors. Asymmetric JAuNNPs allowed facile conjugation of various linkage molecules to fabricate dimeric nanostructures.
呈现了具有不同金壳覆盖率（约 100/75/50/25%）的 Janus 纳米间隙金纳米粒子（JAuNNPs）。部分金壳和核心之间的内部纳米间隙导致了非对称的光学行为；可调性取决于金壳覆盖率和结构不对称性的程度。通过调整亲水和疏水聚合物刷在 Au 核或壳上，壳壳或核核 JAuNNDs（50%）从两亲性 JAuNNPs（50%）自组装而成。由于混合等离子体耦合效应，JAuNNDs 的电磁场增强位置随几何构型而变化。此外，利用 DNA 接头形成 JAuNND（50%）。通过与拉曼分子结合，可以产生比率 SERS 信号，使 JAuNND（50%）能够在活细胞和肿瘤中成像 miR-21 的分布。不对称 JAuNNPs 允许方便地连接各种连接分子来制造二聚体纳米结构。
