Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8110-8114. doi: 10.1002/anie.201702572. Epub 2017 Jun 8.
Janus nanoparticles (JNPs) offer unique features, including the precisely controlled distribution of compositions, surface charges, dipole moments, modular and combined functionalities, which enable excellent applications that are unavailable to their symmetrical counterparts. Assemblies of NPs exhibit coupled optical, electronic and magnetic properties that are different from single NPs. Herein, we report a new class of double-layered plasmonic-magnetic vesicle assembled from Janus amphiphilic Au-Fe O NPs grafted with polymer brushes of different hydrophilicity on Au and Fe O surfaces separately. Like liposomes, the vesicle shell is composed of two layers of Au-Fe O NPs in opposite direction, and the orientation of Au or Fe O in the shell can be well controlled by exploiting the amphiphilic property of the two types of polymers.
Janus 纳米粒子 (JNPs) 具有独特的特性，包括精确控制组成、表面电荷、偶极矩、模块化和组合功能的分布，这使其能够实现对称纳米粒子无法实现的优异应用。 NPs 的组装体表现出与单个 NPs 不同的耦合光学、电子和磁性特性。在此，我们报告了一类由 Janus 两亲性 Au-Fe O NPs 组装而成的新型双层等离子体-磁性囊泡，这些 NPs 分别在 Au 和 Fe O 表面接枝了不同亲水性的聚合物刷。与脂质体类似，囊泡壳由两层相反方向的 Au-Fe O NPs 组成，并且可以通过利用两种聚合物的两亲性来很好地控制 Au 或 Fe O 在壳中的取向。
