Angle Orthod. 2020 May 1;90(3):354-361. doi: 10.2319/072119-483.1.
To investigate the effect of local injection of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement.
Sixteen female patients were randomly allocated in a split-mouth study design to receive PRP injections with CaCl2 activating solution on one side (intervention side) while the other side received CaCl2 injection only (control side). Canine retraction was performed on 0.017 × 0.025-inch stainless steel archwire applying 1.5 N retraction force. PRP and CaCl2 injections were done at 0, 3, and 6 weeks. The duration of the study was 4 months. Data were collected from digitized models. Assessment of pain accompanying the procedure was done using a visual analogue scale.
The rate of canine retraction was faster on the intervention side in the first 2 months, with a statistically significant difference in the first month (P = .049). On the other hand, the rate was statistically significantly slower on the intervention side in the third month following cessation of PRP injections (P = .02). Pain increased following injections on both sides.
PRP showed a positive potential to accelerate the rate of tooth movement when injected in the first 2 months. Repeated injections of PRP to maintain a steady rate of accelerated tooth movement warrant further investigation.
研究富血小板血浆（PRP）局部注射对正畸牙齿移动速度的影响。
将 16 名女性患者随机分配到一项分侧研究设计中，一侧接受 PRP 注射加氯化钙激活液（干预侧），另一侧仅接受氯化钙注射（对照侧）。用 0.017×0.025 英寸不锈钢方丝施加 1.5N 的回弹力进行尖牙后移。在 0、3 和 6 周时进行 PRP 和氯化钙注射。研究持续时间为 4 个月。数据来自数字化模型收集。使用视觉模拟量表评估伴随该过程的疼痛。
在最初的 2 个月内，干预侧的尖牙后移速度更快，第一个月有统计学显著差异（P =.049）。另一方面，在停止 PRP 注射后的第三个月，干预侧的速度明显较慢（P =.02）。两侧注射后疼痛均增加。
PRP 在最初的 2 个月内注射显示出加速牙齿移动速度的积极潜力。为了维持加速牙齿移动的稳定速度，需要进一步研究重复注射 PRP。
