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AMD3100/培利西林通过 CXCL12-KRT19 涂层克服胰腺和结直肠癌细胞的免疫抑制。

AMD3100/Plerixafor overcomes immune inhibition by the CXCL12-KRT19 coating on pancreatic and colorectal cancer cells.

机构信息

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Weill Cornell Medicine, New York, NY, USA.

出版信息

Br J Cancer. 2021 Jul;125(2):149-151. doi: 10.1038/s41416-021-01315-y. Epub 2021 Mar 26.

DOI:10.1038/s41416-021-01315-y
PMID:33772153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8292464/
Abstract

A recent Phase 1 clinical study of the immunological effects of inhibiting the chemokine receptor, CXCR4, in patients with pancreatic ductal adenocarcinoma or colorectal cancer suggests that stimulation of CXCR4 on immune cells suppresses the intratumoural immune reaction. Here, we discuss how CXCR4 mediates this response, and how cancer cells elicit it.

摘要

最近一项关于抑制趋化因子受体 CXCR4 对胰腺导管腺癌或结直肠癌患者免疫影响的 1 期临床研究表明，免疫细胞上 CXCR4 的刺激抑制了肿瘤内的免疫反应。在这里，我们讨论 CXCR4 如何介导这种反应，以及癌细胞如何引发这种反应。

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