Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens Panepistimioupolis, 15771, Athens, Greece.
Chemistry. 2021 May 20;27(29):7915-7922. doi: 10.1002/chem.202100655. Epub 2021 Apr 22.
A cheap, facile and metal-free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen-9-one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been activated and subsequently converted in a one-pot reaction into amides, hydroxamic acids and esters in good to high yields. The applicability of this method was highlighted in the synthesis of Moclobemide, a drug against depression and social anxiety. Extended and detailed mechanistic studies have been conducted, in order to determine a plausible mechanism for the reaction.
一种廉价、简便且无需金属的光化学方法被开发出来，用于激活芳香醛。利用硫代吖啶酮-9-酮作为光催化剂，以及廉价的家用灯具作为光源，各种芳香醛可以在一锅反应中被激活，随后转化为酰胺、羟肟酸和酯，产率良好到很高。该方法在合成抗抑郁和社交焦虑药物吗氯贝胺中的应用得到了强调。为了确定反应的可能机制，进行了扩展和详细的机理研究。
