Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
Org Lett. 2012 Oct 5;14(19):5014-7. doi: 10.1021/ol302175v. Epub 2012 Sep 14.
A one-pot synthesis of amides from aldheydes with N-chloroamines, prepared in situ from amines, has been developed. Both aliphatic and aromatic aldehydes and many types of mono- and disubstituted amines are tolerant in this transformation. This cross-coupling reaction appears simple and convenient, has a wide substrate scope and makes use of cheap, abundant, and easily available reagents.
发展了一种由醛与 N-氯代胺一锅法合成酰胺的方法，其中 N-氯代胺由胺原位制备得到。该转化对脂肪醛和芳香醛以及许多类型的单取代和二取代胺都具有耐受性。此交叉偶联反应操作简单方便，底物适用范围广，且使用了廉价、丰富和易得的试剂。
