Department of Systems Life Engineering, Maebashi Institute of Technology, Maebashi, Gunma, Japan.
Neuropsychopharmacol Rep. 2021 Jun;41(2):215-222. doi: 10.1002/npr2.12177. Epub 2021 Mar 27.
The consolidation of short-term memories into long-term memories is promoted by associations with novel environmental stimuli. This phenomenon is known as behavioral tagging. Neuropsin, a plasticity-related serine protease in the hippocampus and amygdala, is involved in memory formation. This study investigated how neuropsin affects associative long-term memory.
Short-term and long-term memory were assessed in control and neuropsin-deficient mice by investigating their performance in inhibitory avoidance and spatial object recognition tasks. The effect of exposure to novelty on the conversion of short-term memory to associative long-term memory was also examined.
The consolidation of task-related short-term memories into long-term memories was facilitated by exposing the animals to a novel environment 1 hour before training. However, this long-term memory conversion was impaired in neuropsin-deficient mice performing the inhibitory avoidance task but not the spatial object recognition task.
Behavioral tagging occurs via neuropsin-dependent and neuropsin-independent processes for different behavioral tasks.
通过与新环境刺激建立关联，促进短期记忆向长期记忆的巩固。这种现象被称为行为标记。神经蛋白酶是海马体和杏仁核中与可塑性相关的丝氨酸蛋白酶，参与记忆的形成。本研究探讨了神经蛋白酶如何影响联想性长期记忆。
通过抑制性回避和空间物体识别任务来评估对照组和神经蛋白酶缺失小鼠的短期和长期记忆，以研究其表现。还研究了暴露于新奇环境对将短期记忆转化为联想性长期记忆的影响。
在训练前 1 小时将动物暴露于新环境中，有助于与任务相关的短期记忆向长期记忆的巩固。然而，在进行抑制性回避任务的神经蛋白酶缺失小鼠中，这种长期记忆的转换受到损害，但在进行空间物体识别任务的小鼠中则没有。
对于不同的行为任务，行为标记是通过神经蛋白酶依赖和非依赖的过程发生的。
