Sojka J E, Adams S B, Lamar C H, Eller L L
Department of Large Animal Clinics, Purdue University, West Lafayette, IN 47907.
Am J Vet Res. 1988 Apr;49(4):527-9.
Effect of butorphanol, pentazocine, meperidine, and metoclopramide on jejunal and pelvic flexure myoelectric and mechanical activity in 4 female ponies was investigated. The agent to be tested or saline solution was administered IV at the start of a 6-hour recording trial. In the jejunum, duration between activity fronts of regular spiking activity, defined as the length of the migrating myoelectric complex (MMC), was measured. The average duration of the MMC during control trials was 150 +/- 46 minutes. The average duration of the MMC after meperidine, butorphanol, pentazocine, and metoclopramide administration was 295 +/- 70 minutes, 260 +/- 60 minutes, 275 +/- 60 minutes, and 163 +/- 64 minutes, respectively. Meperidine, butorphanol, or pentazocine significantly increased the MMC duration (P less than 0.05), and did not significantly alter the pelvic flexure activity. Seemingly, meperidine, butorphanol, and pentazocine inhibited cyclic myoelectric activity in the jejunum. Metoclopramide had no effect on jejunal or pelvic flexure motility.
研究了布托啡诺、喷他佐辛、哌替啶和甲氧氯普胺对4匹雌性小马空肠和骨盆弯曲处肌电及机械活动的影响。在6小时记录试验开始时，静脉注射受试药物或生理盐水。在空肠中，测量规则锋电位活动的活动前沿之间的持续时间，定义为移行性肌电复合波（MMC）的长度。对照试验期间MMC的平均持续时间为150±46分钟。注射哌替啶、布托啡诺、喷他佐辛和甲氧氯普胺后，MMC的平均持续时间分别为295±70分钟、260±60分钟、275±60分钟和163±64分钟。哌替啶、布托啡诺或喷他佐辛显著增加了MMC持续时间（P＜0.05），且未显著改变骨盆弯曲活动。似乎哌替啶、布托啡诺和喷他佐辛抑制了空肠中的周期性肌电活动。甲氧氯普胺对空肠或骨盆弯曲的运动没有影响。
