School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
J Trace Elem Med Biol. 2021 Jul;66:126742. doi: 10.1016/j.jtemb.2021.126742. Epub 2021 Mar 10.
Diabetes mellitus (DM) is a non-communicable metabolic disease which is closely related to excessive oxidative stress after constant exposure to high plasma glucose. Although the current antidiabetic medications are effective in lowering blood glucose, these medications do not prevent or reverse the disease progression. Thus, there is a crucial need to explore new therapeutic interventions that could address this shortcoming. As cerium oxide nanoparticles (CONPs) possess antioxidant property, this agent may be used as a treatment option for the management of DM.
This review aims to provide a critical evaluation of the pharmacological and antidiabetic effects of CONPs in cell and animal models. The roles of CONPs in attenuating DM complications are also presented in this report.
We conducted a literature search in the PubMed database using the keywords "cerium oxide", "cerous oxide", "ceria", "nanoceria", and "diabetes" from inception to December 2020. The inclusion criteria were primary source articles that investigated the role of CONPs in DM and diabetic complications.
We identified 47 articles from the initial search. After the thorough screening, only 31 articles were included in this study. We found that CONPs can attenuate parameters that are related to DM and diabetic complications in various animals and cell culture models.
CONPs could potentially be used in the treatment of those with DM and complications caused by the disease.
糖尿病（DM）是一种非传染性代谢疾病，与持续暴露于高血糖环境下的过度氧化应激密切相关。尽管目前的抗糖尿病药物在降低血糖方面有效，但这些药物不能预防或逆转疾病进展。因此，迫切需要探索新的治疗干预措施来解决这一不足。由于氧化铈纳米颗粒（CONPs）具有抗氧化特性，因此该药物可作为治疗 DM 的一种选择。
本综述旨在对 CONPs 在细胞和动物模型中的药理学和抗糖尿病作用进行批判性评估。本报告还介绍了 CONPs 在减轻 DM 并发症中的作用。
我们使用“cerium oxide”、“cerous oxide”、“ceria”、“nanoceria”和“diabetes”等关键词在 PubMed 数据库中进行了文献检索，检索时间从建库到 2020 年 12 月。纳入标准为研究 CONPs 在 DM 及糖尿病并发症中的作用的原始研究文章。
我们从最初的搜索中确定了 47 篇文章。经过彻底筛选，只有 31 篇文章被纳入本研究。我们发现 CONPs 可减轻各种动物和细胞培养模型中与 DM 及糖尿病并发症相关的参数。
CONPs 可能可用于治疗 DM 患者和由该疾病引起的并发症。
