Devi N Sanjana, Ganapathy Dhanraj M, Rajeshkumar S, Maiti Subhabrata
Department of Prosthodontics and Implantology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
J Adv Pharm Technol Res. 2022 Dec;13(Suppl 2):S491-S495. doi: 10.4103/japtr.japtr_196_22. Epub 2022 Dec 30.
The aim of this study is to analyze and characterize the antimicrobial effect of cerium oxide nanoparticles (NP) synthesized using neem and ginger. Finely grounded neem and ginger powder were taken and mixed with distilled water. This mixture was then heated and filtered. Ammonium cerium nitrate dissolved in distilled water. Both the mixtures were mixed and stirred magnetically. A double-beam ultraviolet-visible spectrophotometer was used to monitor color changes. The extract was centrifuged at 8000 rpm for 15 min. The final pellet was powdered using a hot air oven at 70°C for 24 h. Visualization was done by transmission electron microscopy and spherical morphology was noted, with an average diameter of 5 nm, in aggregated form. The sample containing 100 mg of cerium oxide shows the most significant effect on the zone of inhibition of 11 mm of . The results obtained in the current study confirmed that CeO-NP possessed antioxidant and cytotoxic properties.
本研究的目的是分析和表征使用印楝和生姜合成的氧化铈纳米颗粒（NP）的抗菌效果。取磨细的印楝和生姜粉末并与蒸馏水混合。然后将该混合物加热并过滤。硝酸铈铵溶解于蒸馏水中。将两种混合物混合并进行磁力搅拌。使用双光束紫外可见分光光度计监测颜色变化。提取物在8000转/分钟下离心15分钟。最终沉淀在70°C的热风烘箱中干燥24小时制成粉末。通过透射电子显微镜进行观察，发现呈聚集形式，平均直径为5纳米的球形形态。含有100毫克氧化铈的样品对抑菌圈显示出最显著的效果，抑菌圈为11毫米。当前研究获得的结果证实CeO-NP具有抗氧化和细胞毒性特性。
