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2019-2020 流感季期间,国防部受益人群中的流感监测趋势和流感疫苗有效性。

Influenza Surveillance Trends and Influenza Vaccine Effectiveness Among Department of Defense Beneficiaries During the 2019-2020 Influenza Season.

出版信息

MSMR. 2021 Mar;28(3):2-8.

PMID:33773566
Abstract

Laboratory-based influenza surveillance was conducted in the 2019-2020 influenza season among Department of Defense (DoD) beneficiaries through the DoD Global Respiratory Pathogen Surveillance Program (DoDGRS). Sentinel and participating sites submitted 28,176 specimens for clinical diagnostic testing. A total of 5,529 influenza-positive cases were identified. Starting at surveillance week 45 (3-9 November 2019), influenza B was the predominant influenza type, followed by high activity of influenza A(H1N1)pdm09 three weeks thereafter. Both influenza B and influenza A(H1N1)pdm09 were then highly co-circulated through surveillance week 13 (22-28 March 2020). End-of-season influenza vaccine effectiveness (VE) was estimated using a test-negative case-control study design. The adjusted end-of-season VE for all beneficiaries, regardless of influenza type or subtype, was 46% (95% confidence interval: 40%-52%). The influenza vaccine was moderately effective against influenza viruses during the 2019-2020 influenza season.

摘要

在 2019-2020 流感季,通过国防部全球呼吸道病原体监测计划(DoDGRS),对国防部受益人进行了基于实验室的流感监测。哨点和参与机构提交了 28176 份用于临床诊断检测的标本。共发现 5529 例流感阳性病例。从监测第 45 周(2019 年 11 月 3 日至 9 日)开始,乙型流感成为主要流感类型,三周后甲型 H1N1pdm09 流感的活跃度较高。此后,乙型流感和甲型 H1N1pdm09 一直高度共同流行,直到监测第 13 周(2020 年 3 月 22 日至 28 日)。使用病例对照检验阴性设计估计了季节性流感疫苗的期末有效性。无论流感类型或亚型如何,所有受益人的期末调整疫苗有效性为 46%(95%置信区间:40%-52%)。在 2019-2020 流感季,流感疫苗对流感病毒的有效性为中等。

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