Bioflavors and Bioactive Compounds Laboratory, Department of Food Science, School of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil.
Bioflavors and Bioactive Compounds Laboratory, Department of Food Science, School of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil; Nutrition and Metabolism Laboratory, Department of Food and Nutrition, School of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil.
Food Res Int. 2021 Apr;142:110182. doi: 10.1016/j.foodres.2021.110182. Epub 2021 Feb 8.
This review combined scientific data regarding the use of genus Eugenia plants for the management of diabetes. Diabetes mellitus is a chronic metabolic disease mainly characterized by hyperglycaemia, which can lead to serious health complications. Scientists have been seeking therapeutic compounds in plants, reporting the species of the genus Eugenia as a potential source of phytochemicals with antidiabetic properties. In vitro and in vivo studies have proved that the bioactive compounds in the genus Eugenia can positively affect the biomarkers of diabetes. We discussed the phytochemical profile of the genus Eugenia and its mechanism of action on diabetes, which could modulate carbohydrate metabolism, glucose homeostasis, and insulin secretion, inhibit carbohydrases and reduce oxidative stress, suppressing the formation of advanced glycation end-products and protecting/regenerating pancreatic β-cells. Therefore, plants of the genus Eugenia showed therapeutic potential to be used in the treatment of diabetes and its comorbidities.
这篇综述综合了有关利用桃金娘属植物治疗糖尿病的科学数据。糖尿病是一种慢性代谢疾病，主要特征为高血糖，可导致严重的健康并发症。科学家一直在植物中寻找治疗化合物，报告称桃金娘属植物可能是具有抗糖尿病特性的植物化学物质的潜在来源。体外和体内研究已经证明，桃金娘属植物中的生物活性化合物可以积极影响糖尿病的生物标志物。我们讨论了桃金娘属植物的植物化学特征及其对糖尿病的作用机制，它可以调节碳水化合物代谢、葡萄糖稳态和胰岛素分泌，抑制糖苷酶并减少氧化应激，抑制晚期糖基化终产物的形成并保护/再生胰岛β细胞。因此，桃金娘属植物具有治疗糖尿病及其合并症的治疗潜力。
