Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam UMC-location VUMC/Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Netherlands Comprehensive Cancer Organization (IKNL), Department of Research and Development, Utrecht, The Netherlands; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Int J Oral Maxillofac Surg. 2022 Jan;51(1):18-26. doi: 10.1016/j.ijom.2021.03.006. Epub 2021 Mar 25.
There has been an increasing trend in oral squamous cell carcinoma (OSCC) in patients under 45 years of age. The aim of this study was to evaluate the burden of OSCC in the Netherlands between 1989 and 2018 among young adults (age 20-34 years) when compared to adults (age 35-44 years), and to describe the burden in older groups as well, utilizing cancer registry data to characterize incidence patterns by age, sex, and risk factors. A total of 18,963 cases of OSCC were reported. The overall incidence rate, as measured by annual percentage change (APC), increased significantly from 1989 to 2010 by 1.3% per year (95% confidence interval (CI) 0.9-1.7%) but decreased thereafter by -0.9% (95% CI -2.5% to 0.7%). Annual incidence increased significantly by 2.4% (95% CI 1.1-3.8%) for patients aged 20-34 years, while it decreased for those aged 35-44 years by -0.9% (95% CI -1.7% to 0.0%). In patients older than 60 years, incidence rates increased overall (60-74 years: APC 1.8%, 95% CI 1.5-2.1%; ≥75 years: APC 1.5%, 95% CI 1.2-1.9%). Overall, 66.5% of patients were smokers and 65.3% were alcohol consumers. The marked differences in incidence within the young age subgroups warrants further investigation to elucidate any likely disparity in biological process and clinical outcomes in these populations.
在年龄在 45 岁以下的患者中，口腔鳞状细胞癌（OSCC）的发病率呈上升趋势。本研究旨在评估 1989 年至 2018 年期间荷兰年轻成年人（20-34 岁）与成年人（35-44 岁）之间 OSCC 的负担，并描述年龄较大组别的负担，利用癌症登记数据按年龄、性别和危险因素描述发病模式。共报告了 18963 例 OSCC 病例。总体发病率，以年百分比变化（APC）衡量，从 1989 年到 2010 年以每年 1.3%的速度显著增加（95%置信区间（CI）为 0.9%-1.7%），但此后下降了 0.9%（95%CI -2.5%至 0.7%）。20-34 岁患者的年发病率显著增加 2.4%（95%CI 1.1%-3.8%），而 35-44 岁患者的年发病率下降 0.9%（95%CI -1.7%至 0.0%）。60-74 岁患者的发病率总体上升（APC 1.8%，95%CI 1.5%-2.1%），≥75 岁患者的发病率上升（APC 1.5%，95%CI 1.2%-1.9%）。总体而言，66.5%的患者为吸烟者，65.3%为酒精消费者。年轻年龄亚组内发病率的显著差异需要进一步研究，以阐明这些人群中可能存在的生物学过程和临床结果差异。
