Department of Food Biofunctionality, Institute of Nutritional Sciences, University of Hohenheim, Germany.
Department of Food Biofunctionality, Institute of Nutritional Sciences, University of Hohenheim, Germany.
Redox Biol. 2021 Jun;42:101937. doi: 10.1016/j.redox.2021.101937. Epub 2021 Mar 6.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western nations and characterized by excessive accumulation of lipids in the liver. In this narrative review, we summarize the evidence from human trials that free radical-induced oxidation of macromolecules, in particular of lipids, is a characteristic feature of NAFLD and non-alcoholic steatohepatitis (NASH). We further synthesize the data in the scientific literature describing the impact of vitamin E (mainly α-tocopherol) on concentrations of redox biomarkers in liver biopsies from patients with NAFLD as well as animal experiments. In summary, the available evidence from clinical trials suggests that reactive species-mediated damage to macromolecules, predominantly lipids, occurs in NAFLD and NASH and that daily supplementation with at least 200 I.U. α-tocopherol may alleviate oxidative stress in the liver of NAFLD patients. We propose α-tocopherol as a useful model substance to identify and validate suitable redox biomarkers that may be employed in future clinical trials of new therapeutics for NAFLD.
非酒精性脂肪性肝病 (NAFLD) 是西方国家最常见的肝脏疾病，其特征是肝脏内脂质过度积聚。在这篇叙述性综述中，我们总结了来自人体试验的证据，即自由基诱导的大分子氧化，特别是脂质氧化，是 NAFLD 和非酒精性脂肪性肝炎 (NASH) 的一个特征。我们进一步综合了科学文献中的数据，描述了维生素 E（主要是α-生育酚）对 NAFLD 患者肝活检中氧化还原生物标志物浓度以及动物实验的影响。总之，来自临床试验的现有证据表明，活性物质介导的主要是脂质的大分子损伤发生在 NAFLD 和 NASH 中，每天补充至少 200IUα-生育酚可能缓解 NAFLD 患者肝脏的氧化应激。我们提出α-生育酚作为一种有用的模型物质，以鉴定和验证合适的氧化还原生物标志物，这些标志物可能用于未来 NAFLD 新疗法的临床试验。
