儿科肿瘤患者口腔黏膜炎发生的相关危险因素：系统评价与荟萃分析。
Risk factors associated with the development of oral mucositis in pediatric oncology patients: Systematic review and meta-analysis.
作者信息
de Farias Gabriel Amanda, Silveira Felipe Martins, Curra Marina, Schuch Lauren Frenzel, Wagner Vivian Petersen, Martins Marco Antonio Trevizani, da Silveira Matte Ursula, Siebert Marina, Botton Mariana Rodrigues, Brunetto André Tesainer, Gregianin Lauro José, Martins Manoela Domingues
机构信息
Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
出版信息
Oral Dis. 2022 May;28(4):1068-1084. doi: 10.1111/odi.13863. Epub 2021 Apr 9.
OBJECTIVES
Oral mucositis (OM) is an acute toxicity related to cancer treatment. This systematic review aimed to identify potential risk factors associated with the development of OM in pediatric cancer patients.
METHODS
A search was performed in four electronic databases to identify studies that analyzed risk factors for OM in pediatric cancer patients.
RESULTS
Nineteen articles were included. The incidence of OM ranged from 20% to 80.4%. Chemotherapeutic agents were potential risk factors for OM in eight (42%) studies. Hematological, hepatic, and renal parameters were also considered in eight (42%) studies, while specific individual factors were reported in five (26.3%) studies. Baseline disease, oral microbiota, genetic profile, and biomarkers were reported in four (21.5%) studies each. Meta-analysis showed that groups submitted to high-risk chemotherapy for OM had a 2.79-fold increased risk of OM.
CONCLUSIONS
Identifying risk factors for OM is essential in order to allow individualized and early prevention treatment.
目的
口腔黏膜炎（OM）是一种与癌症治疗相关的急性毒性反应。本系统评价旨在确定小儿癌症患者发生OM的潜在危险因素。
方法
在四个电子数据库中进行检索，以识别分析小儿癌症患者OM危险因素的研究。
结果
纳入19篇文章。OM的发生率在20%至80.4%之间。在八项（42%）研究中，化疗药物是OM的潜在危险因素。八项（42%）研究还考虑了血液学、肝脏和肾脏参数，而五项（26.3%）研究报告了特定的个体因素。四项（21.5%）研究分别报告了基线疾病、口腔微生物群、基因谱和生物标志物。荟萃分析表明，接受OM高风险化疗的组发生OM的风险增加2.79倍。
结论
识别OM的危险因素对于实现个体化和早期预防治疗至关重要。
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