O-糖基化在人类疾病中的作用。
The role of O-glycosylation in human disease.
机构信息
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal.
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal; FMUP - Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
出版信息
Mol Aspects Med. 2021 Jun;79:100964. doi: 10.1016/j.mam.2021.100964. Epub 2021 Mar 26.
O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies.
O-糖基化是蛋白质翻译后高度频繁的修饰，在生理和疾病环境中都具有重要的功能意义。O-聚糖的生物合成依赖于细胞糖基化机制的多个层次的调节，具有器官、组织和细胞特异性。本综述提供了 O-聚糖生物合成和修饰的分子机制的见解，并强调了由异常细胞 O-糖基化引发或调节的疾病的说明性实例。特别关注糖基化遗传疾病、传染病和癌症。最后，我们探讨了 O-聚糖及其生物合成途径作为新型治疗策略靶点的潜力。
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