Sugar A M, Restrepo A, Stevens D A
Am Rev Respir Dis. 1984 Feb;129(2):340-2.
A case of reactivated paracoccidioidomycosis in an immunosuppressed host is described, the first association of this disease with renal transplantation. His presentation and clinical course was similar to the general experience with this mycosis. his response to ketoconazole was delayed when compared with that in non-immunosuppressed patients. Ketoconazole produced a dramatic resolution of all symptoms within 7 months. Serial determinations of paracoccidioides complement fixing antibodies showed falling titers, accurately reflecting his clinical status. Comparisons are made with other endemic mycoses in immunosuppressed patients. More cases of paracoccidioidomycosis in immunosuppressed patients can be expected to occur as immunosuppressive therapy becomes more common in areas endemic for Paracoccidioides brasiliensis, and with current trends in migration and travel.
本文描述了一例免疫抑制宿主中复发的副球孢子菌病病例，这是该疾病首次与肾移植相关联。其临床表现和病程与这种真菌病的一般情况相似。与非免疫抑制患者相比，他对酮康唑的反应有所延迟。酮康唑在7个月内使所有症状显著缓解。连续测定副球孢子菌补体结合抗体显示滴度下降，准确反映了他的临床状况。文中还将其与免疫抑制患者中的其他地方性真菌病进行了比较。随着免疫抑制治疗在巴西副球孢子菌流行地区变得更加普遍，以及当前的移民和旅行趋势，预计免疫抑制患者中会出现更多副球孢子菌病病例。
