Milosevic Dragana, Panin Violeta Lukic
Department of Laboratory Diagnostics, Health Care Center »Dr Milorad Mika Pavlovic«, Indjija, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
J Med Biochem. 2019 Mar 3;38(2):164-171. doi: 10.2478/jomb-2018-0021. eCollection 2019 Apr.
Diabetes mellitus (DM) with its micro- and macrocomplications is the leading global epidemic of the 21st century. The aim of the research is to determine possible changes in the complete blood count (CBC) parameters depending on glycemic controlin patients with Type 2 diabetes mellitus (T2DM).
The study included a total of 178 patients with T2DM, both gender over the age of 40 years, from the Health Care Center »Dr Milorad Mika Pavlović« Indjija, Serbia. To notice the possible correlation between the CBC parameters and glucose control in T2DM, the subjects were divided in two groups with HbA1c ≤ 7% and with HbA1c>7%. We analysed CBC parameters, parameters of glycoregulation, lipid status using standard biochemical methods, performed anthropometric measurements and collected patients data by questionnaire and electronic patient card.
There was statistical difference between HbA1c groups for PMDW (p=0.045), HDL (p=0.0067). Using univariate linear regression it is shown that PCT was correlated with WBC (p=0.0005), neutrophils (p=0.046), monocytes (p=0.003); MPM was associated with MPV (p=0.0005); MPC (p=0.0005), PDW (P=0.0005), GLU0 (p=0.034), HDL-C (p=0.005); PMDW was correlated with HbA1c% (p=0.049), GLU0 (p=0.013), HDL-C (p=0.001), BW (p=0.043) in all patients.
Based on our study results it may be concluded that some of the parameters of CBC could be useful tool in following glycemic control of diabetics.
伴有微血管和大血管并发症的糖尿病（DM）是21世纪全球主要的流行病。本研究的目的是确定2型糖尿病（T2DM）患者全血细胞计数（CBC）参数随血糖控制情况可能发生的变化。
该研究共纳入了来自塞尔维亚因吉亚“米洛拉德·米卡·帕夫洛维奇博士”医疗中心的178例40岁以上的T2DM患者，男女不限。为了观察T2DM患者CBC参数与血糖控制之间的可能相关性，将受试者分为两组，糖化血红蛋白（HbA1c）≤7%组和HbA1c>7%组。我们使用标准生化方法分析了CBC参数、糖调节参数、血脂状况，进行了人体测量，并通过问卷调查和电子病历收集了患者数据。
HbA1c组间在血小板平均分布宽度（PMDW，p = 0.045）、高密度脂蛋白（HDL，p = 0.0067）方面存在统计学差异。单变量线性回归分析显示，血小板压积（PCT）与白细胞（WBC，p = 0.0005）、中性粒细胞（p = 0.046）、单核细胞（p = 0.003）相关；平均血小板质量（MPM）与平均血小板体积（MPV，p = 0.0005）相关；平均血小板浓度（MPC，p = 0.0005）、血小板分布宽度（PDW，P = 0.0005）、空腹血糖（GLU0，p = 0.034）、高密度脂蛋白胆固醇（HDL-C，p = 0.005）相关；在所有患者中，PMDW与HbA1c%（p = 0.049）、GLU0（p = 0.013）、HDL-C（p = 0.001）、体重（BW，p = 0.043）相关。
基于我们的研究结果，可以得出结论，CBC的一些参数可能是监测糖尿病患者血糖控制的有用工具。
