Nishimaki-Mogami T, Minegishi K, Tanaka A, Sato M
Division of Medical Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan.
Arch Toxicol. 1988;61(4):259-64. doi: 10.1007/BF00364847.
The metabolic fate of 2-ethylhexyl diphenyl phosphate (EHDPP) was studied in male rats. Orally administered 14C-EHDPP was rapidly absorbed and about 80% of the radioactivity was excreted in the urine and feces in the first 24 h. By 7 days, 48% and 52% of the radioactivity was recovered in urine and feces, respectively. Since biliary excretion was low (6% for 2 days), urine seems to be the major excretion route of EHDPP. Radioactivity was widely distributed in all tissues examined. At 2 h, the concentration was relatively high in blood, liver kidney and adipose tissue. The elimination of radioactivity from adipose tissue and liver was somewhat delayed, but almost all the radioactivity was eliminated by 7 days. The major metabolites in the urine were diphenyl phosphate (DPP) and phenol. p-Hydroxyphenyl phenyl phosphate (OH-DPP) and monophenyl phosphate (MPP) were also identified as minor metabolites.
在雄性大鼠中研究了磷酸二（2-乙基己基）苯酯（EHDPP）的代谢命运。口服给予的14C-EHDPP被迅速吸收，约80%的放射性在最初24小时内通过尿液和粪便排出。到第7天，分别在尿液和粪便中回收了48%和52%的放射性。由于胆汁排泄量较低（2天内为6%），尿液似乎是EHDPP的主要排泄途径。放射性广泛分布于所有检测的组织中。在2小时时，血液、肝脏、肾脏和脂肪组织中的浓度相对较高。脂肪组织和肝脏中放射性的消除有所延迟，但到第7天时几乎所有放射性都已消除。尿液中的主要代谢产物是磷酸二苯酯（DPP）和苯酚。对羟基苯基苯基磷酸酯（OH-DPP）和单苯基磷酸酯（MPP）也被鉴定为次要代谢产物。
