Biyabani Syed Raziuddin, Talati Jamsheer, Umer Daniya, Kazmi Zehra, Soomro Hussamuddin, Mansoor Rubab
Surgery, The Aga Khan University, Karachi, PAK.
Surgery, The Aga Khan University Hospital, Karachi, PAK.
Cureus. 2021 Feb 21;13(2):e13464. doi: 10.7759/cureus.13464.
Renal and ureteric stones (RS) can form due to genetic, metabolic, environmental, and diet-hydration related factors. Studies have shown that patients with family history (FH) of RS have higher likelihood of recurrence.
We conducted a retrospective cross-sectional study on 114 pedigrees to investigate the impact of FH on recurrence of RS and examine patterns of inheritance. Results: Family history of renal stone disease was found in 42% of all patients. There was a significant increase of stone recurrence in RS patients with a positive FH (p=0.001). Seventy-one percent of patients with recurrent stones had at least one family member with RS. Interestingly, male penetrance was higher in RS recurrence, where a greater proportion of males had no FH of RS, indicating that there may be other factors involved as well. Conclusion: Family history in RS patients should be continuously explored for the possible underlying genetic influence, whilst keeping in mind the dietary habits of the family.
肾和输尿管结石（RS）可因遗传、代谢、环境以及饮食-水分相关因素而形成。研究表明，有RS家族史（FH）的患者复发可能性更高。
我们对114个家系进行了一项回顾性横断面研究，以调查FH对RS复发的影响并研究遗传模式。结果：在所有患者中，42%有肾结石病家族史。FH呈阳性的RS患者结石复发率显著增加（p=0.001）。71%的复发性结石患者至少有一名家庭成员患有RS。有趣的是，RS复发中男性外显率更高，其中较大比例的男性没有RS家族史，这表明可能还涉及其他因素。结论：应持续探究RS患者的家族史，以寻找可能存在的潜在遗传影响，同时牢记家族的饮食习惯。
