Not a Tumor-Nonspecific Orbital Inflammation.

This study was aimed to illustrate the features and complexities of nonspecific orbital inflammation via discussion of two representative cases.  Present study is a retrospective case review.  The study was conducted at a tertiary care medical center.  Two patients with nonspecific orbital inflammation were participants of this retrospective study.  Outcome of the study was disease-free patients and off all medications.  At follow-up, both patients are disease free and off all medications.  Surgery plays a diagnostic and therapeutic role. While the clinical subtype is important for differential diagnosis and symptomatic treatment, the histologic subtype is similarly important. For inflammatory dacryoadenitis, surgery can be therapeutic. For extensive granulomatosis with polyangiitis, debulking surgery may allow better penetration of medications, especially rituximab.