骨再生免疫工程在骨免疫调节中的新见解。
New insight of immuno-engineering in osteoimmunomodulation for bone regeneration.
作者信息
Ouyang Long, Cao Jiankun, Dai Qiang, Qiu Daojing
机构信息
Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Orthopedics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
出版信息
Regen Ther. 2021 Mar 19;18:24-29. doi: 10.1016/j.reth.2021.03.003. eCollection 2021 Dec.
Abstract
With the continuous development of bone tissue engineering, the importance of immune response in bone tissue regeneration is gradually recognized. The new bone tissue engineering products should possess immunoregulatory functions, harmonizing the interactions between the bone's immune defense and regeneration systems, and promoting tissue regeneration. This article will interpret the relationship between the bone immune system, bone tissue regeneration, as well as the immunoregulatory function of bone biomaterials and seed stem cells in bone tissue engineering. This review locates arears for foucusing efforts at providing novel designs ideas about the development of immune-mediation targeted bone tissue engineering products and the evaluation strategy for the osteoimmunomodulation property of bone biomaterials.
摘要
随着骨组织工程的不断发展，免疫反应在骨组织再生中的重要性逐渐得到认可。新型骨组织工程产品应具备免疫调节功能，协调骨骼免疫防御与再生系统之间的相互作用，促进组织再生。本文将阐释骨免疫系统、骨组织再生以及骨生物材料和种子干细胞在骨组织工程中的免疫调节功能之间的关系。本综述旨在为免疫介导靶向骨组织工程产品的开发提供新颖的设计思路以及骨生物材料骨免疫调节特性的评估策略，确定重点研究领域。
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