Höbaus Clemens, Pesau Gerfried, Zierfuss Bernhard, Koppensteiner Renate, Schernthaner Gerit-Holger
Division of Angiology, Department of Internal Medicine II, 27271Medical University Vienna, Vienna, Austria.
Angiology. 2021 Oct;72(9):855-860. doi: 10.1177/00033197211004393. Epub 2021 Mar 29.
We evaluated angiogenin as a prospective biomarker in peripheral artery disease (PAD) patients with and without claudication symptoms. A pilot study suggested an elevation of angiogenin in critical limb ischemia. However, in PAD patients, the predictive value of angiogenin has not yet been evaluated. For this purpose, 342 patients with PAD (age: 69 ± 10 years, 34.5% women) were followed-up for 7 years in a cross-sectional study. Angiogenin was measured by enzyme-linked immunosorbent assay. All-cause and cardiovascular mortality were analyzed by Cox regression. Angiogenin levels were higher in men ( = .001) and were associated with patient waist-to-hip ratio ( < .001), fasting triglycerides ( = .011), and inversely with estimated glomerular filtration rate ( = .009). However, angiogenin showed no association with age, characteristics of diabetes, markers of lipid metabolism, or C-reactive protein. Angiogenin did not correlate with markers of angiogenesis such as vascular endothelial growth factor, angiopoietin-2, or tie-2. Furthermore, angiogenin was not associated with PAD Fontaine stages or with patient ankle-brachial index in addition to all-cause mortality (hazard ratio [HR] = 1.09 [95% CI: 0.89-1.34]) or cardiovascular morality (HR = 1.05 [0.82-1.35]). These results suggest that angiogenin does not provide further information regarding outcome prediction in patients with PAD.
我们评估了血管生成素作为有或无间歇性跛行症状的外周动脉疾病（PAD）患者的一种潜在生物标志物。一项初步研究表明，在严重肢体缺血患者中血管生成素水平升高。然而，在PAD患者中，血管生成素的预测价值尚未得到评估。为此，在一项横断面研究中，对342例PAD患者（年龄：69±10岁，女性占34.5%）进行了7年的随访。采用酶联免疫吸附测定法检测血管生成素。通过Cox回归分析全因死亡率和心血管死亡率。男性的血管生成素水平较高（P = 0.001），且与患者的腰臀比相关（P < 0.001）、空腹甘油三酯相关（P = 0.011），与估计肾小球滤过率呈负相关（P = 0.009）。然而，血管生成素与年龄、糖尿病特征、脂质代谢标志物或C反应蛋白均无关联。血管生成素与血管生成标志物如血管内皮生长因子、血管生成素-2或Tie-2均无相关性。此外，除全因死亡率（风险比[HR]=1.09[95%CI：0.89 - 1.34]）或心血管死亡率（HR = 1.05[0.82 - 1.35]）外，血管生成素与PAD Fontaine分期或患者踝臂指数均无关联。这些结果表明，血管生成素并不能为PAD患者的预后预测提供更多信息。
