慢性完全闭塞患者血清血管生成素和骨桥蛋白水平与冠状动脉侧支循环的关系。
The association between serum angiogenin and osteopontin levels and coronary collateral circulation in patients with chronic total occlusion.
作者信息
Gürses Kadri Murat, Yalçın Muhammed Ulvi, Koçyiğit Duygu, Beşler Muhammed Said, Canpınar Hande, Evranos Banu, Yorgun Hikmet, Şahiner Mehmet Levent, Kaya Ergün Barış, Özer Necla, Güç Dicle, Aytemir Kudret, Tokgözoğlu Lale
机构信息
Department of Basic Medical Sciences, Faculty of Medicine, Adnan Menderes University; Aydın-Turkey.
Department of Cardiology, Faculty of Medicine, Selçuk University; Konya-Turkey.
出版信息
Anatol J Cardiol. 2019 Aug;22(2):77-84. doi: 10.14744/AnatolJCardiol.2019.88555.
OBJECTIVE
A well-developed coronary collateral circulation lowers both in-hospital and long-term morbidity and mortality limiting the infarct. Angiogenin (AGN) and osteopontin (OPN) are known to be potent inducers of angiogenesis. The aim of the present study was to investigate the relationship between serum ANG and OPN levels and collateral filling grade in subjects with stable coronary artery disease (SCAD).
METHODS
A total of 122 age- and gender-matched consecutive patients who were found to have total occlusion (n=70) and no significant stenosis in epicardial coronary arteries (n=52) who underwent coronary angiography due to SCAD between January 2015 and July 2017 were included in the study. AGN and OPN levels were measured using enzyme linked immunosorbent assay. Coronary collateral circulation was graded using Rentrop's classification of collateral filling.
RESULTS
A total of 52 patients (61.60±11.78 years, 61.5% male) without significant epicardial coronary artery stenosis and 70 patients (62.87±8.24 years, 65.7% male) with totally occluded coronary arteries were included in the study. Subjects with total occlusion had significantly higher levels of AGN [122.00 (79.00-623.00) pg/mL vs. 98.00 (18.00-160.00) pg/mL, p<0.001] and OPN [1863.50 (125.00-6500.00) pg/mL vs. 451.00 (112.00- 1850.00) pg/mL, p<0.001] than those without significant stenosis. In addition, AGN [127.00 (87.00-623.00) pg/mL vs. 110.00 (79.00-188.00) pg/mL, p=0.011] and OPN [2681.00 (126.00-6500.00) pg/mL vs. 649.00 (125.00-4255.00) pg/mL, p=0.001] levels were significantly higher in patients with better developed collaterals. Serum AGN and OPN levels were found to be significantly associated with coronary collateral development.
CONCLUSION
AGN and OPN are associated with better developed coronary collateral circulation and may have therapeutic implications for the promotion of coronary collateral development.
目的
完善的冠状动脉侧支循环可降低住院期间及长期的发病率和死亡率，限制梗死范围。血管生成素（AGN）和骨桥蛋白（OPN）是已知的强大血管生成诱导剂。本研究旨在探讨稳定型冠状动脉疾病（SCAD）患者血清ANG和OPN水平与侧支循环充盈分级之间的关系。
方法
纳入2015年1月至2017年7月期间因SCAD接受冠状动脉造影的122例年龄和性别匹配的连续患者，其中发现冠状动脉完全闭塞者70例，心外膜冠状动脉无明显狭窄者52例。采用酶联免疫吸附测定法测量AGN和OPN水平。使用Rentrop侧支循环充盈分类法对冠状动脉侧支循环进行分级。
结果
本研究共纳入52例心外膜冠状动脉无明显狭窄的患者（61.60±11.78岁，男性占61.5%）和70例冠状动脉完全闭塞的患者（62.87±8.24岁，男性占65.7%）。完全闭塞的患者AGN水平[122.00（79.00 - 623.00）pg/mL vs. 98.00（18.00 - 160.00）pg/mL，p<0.001]和OPN水平[1863.50（125.00 - 6500.00）pg/mL vs. 451.00（112.00 - 1850.00）pg/mL，p<0.001]显著高于无明显狭窄的患者。此外，侧支循环较好的患者AGN水平[127.00（87.00 - 623.00）pg/mL vs. 110.00（79.00 - 188.00）pg/mL，p = 0.011]和OPN水平[2681.00（126.00 - 6500.00）pg/mL vs. 649.00（125.00 - 4255.00）pg/mL，p = 0.001]也显著更高。血清AGN和OPN水平与冠状动脉侧支循环发育显著相关。
结论
AGN和OPN与更完善的冠状动脉侧支循环相关，可能对促进冠状动脉侧支循环发育具有治疗意义。
Zotero 插件