Duthie D J, Rowbotham D J, Wyld R, Henderson P D, Nimmo W S
Department of Anaesthesia, Sheffield University Medical School.
Br J Anaesth. 1988 May;60(6):614-8. doi: 10.1093/bja/60.6.614.
Plasma fentanyl concentrations were measured during and after transdermal fentanyl delivery in groups of patients undergoing general surgery. At 8 and 12 h, concentrations did not differ from those observed in a matched group of patients receiving fentanyl by i.v. infusion. At 24 h, concentrations were significantly lower in one of the transdermal groups. Plasma fentanyl clearance did not differ significantly between the groups. Plasma fentanyl concentrations decreased slowly after removal of the transdermal system.
在接受普通外科手术的患者组中，于经皮给予芬太尼期间及之后测量血浆芬太尼浓度。在8小时和12小时时，其浓度与通过静脉输注接受芬太尼的匹配患者组中观察到的浓度无差异。在24小时时，其中一个经皮给药组的浓度显著较低。各组之间血浆芬太尼清除率无显著差异。去除经皮给药系统后，血浆芬太尼浓度下降缓慢。
