Mosaiques Diagnostics GmbH, Hannover, Germany.
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Expert Rev Proteomics. 2021 Feb;18(2):137-157. doi: 10.1080/14789450.2021.1908893. Epub 2021 Apr 8.
Chronic kidney disease is avery common and complex chronic disease. Uncovering the pathological patterns of CKD on the molecular level of bio-fluids and tissue appears to be both vital and promising for a more favorable outcome. We reviewed recently discovered proteomics biomarkers for CKD to provide new insight into disease pathology.
We review the application of proteome analysis in the context of CKD with various etiologies within the last 5 years. Proteins and peptides associated with CKD as derived from multiple sources (urine, blood and tissue) are reported along with their various biological pathways.
A systematic and theoretical comprehension of the CKD pathology is essential for its successful management. The underlying complexity of the disease further requires specific conditions for reliable and interpretable results. In this context, clinical proteomics has resulted in first encouraging findings in CKD. A more complete understanding of the biological pathways related to the disease, based on the scope of a holistic proteomic approach, could improve substantially the management of CKD, especially when in conjunction with the current trend of personalized medicine.
慢性肾脏病是一种非常常见且复杂的慢性疾病。在生物液体和组织的分子水平上揭示 CKD 的病理模式，对于获得更好的结果似乎至关重要且充满希望。我们回顾了最近发现的 CKD 蛋白质组学生物标志物，以期为疾病病理学提供新的见解。
我们回顾了过去 5 年内不同病因 CKD 中蛋白质组分析的应用。报告了源自多种来源（尿液、血液和组织）的与 CKD 相关的蛋白质和肽及其各种生物学途径。
要成功管理 CKD，必须对其病理有系统和理论上的理解。该疾病的内在复杂性还需要特定的条件才能获得可靠和可解释的结果。在这种情况下，临床蛋白质组学在 CKD 方面取得了令人鼓舞的初步发现。基于整体蛋白质组学方法的范围，对与疾病相关的生物学途径有更全面的了解，将极大地改善 CKD 的管理，特别是与当前个性化医疗的趋势相结合时。
