Department of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea.
J Microbiol. 2021 Apr;59(4):341-359. doi: 10.1007/s12275-021-0650-6. Epub 2021 Mar 29.
RNA metabolism needs to be tightly regulated in response to changes in cellular physiology. Ribonucleases (RNases) play an essential role in almost all aspects of RNA metabolism, including processing, degradation, and recycling of RNA molecules. Thus, living systems have evolved to regulate RNase activity at multiple levels, including transcription, post-transcription, post-translation, and cellular localization. In addition, various trans-acting regulators of RNase activity have been discovered in recent years. This review focuses on the physiological roles and underlying mechanisms of trans-acting regulators of RNase activity.
RNA 代谢需要根据细胞生理变化进行严格调控。核糖核酸酶（RNases）在 RNA 代谢的几乎所有方面都发挥着重要作用，包括 RNA 分子的加工、降解和再循环。因此，生命系统已经进化到在多个层面上调节 RNase 活性，包括转录、转录后、翻译后和细胞定位。此外，近年来还发现了各种 RNA 酶活性的反式作用调节剂。本综述重点介绍了 RNA 酶活性的反式作用调节剂的生理作用和潜在机制。
