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在英国,COVID-19 大流行期间因髋部骨折入院的患者 30 天死亡率增加。

Increased 30-day mortality rate in patients admitted with hip fractures during the COVID-19 pandemic in the UK.

机构信息

Trauma and Orthopaedics Department, Norfolk and Norwich University Hospital, Norwich, UK.

出版信息

Eur J Trauma Emerg Surg. 2021 Oct;47(5):1327-1334. doi: 10.1007/s00068-021-01649-5. Epub 2021 Mar 30.

Abstract

INTRODUCTION

Hip fractures are the most common traumatic injury in the UK's elderly population. Patients are often extremely frail with multiple comorbidities and so are at high risk of death should they contract COVID-19. This study aims to quantify the effects of COVID-19 on patients presenting with hip fractures to the Norfolk and Norwich University Hospital (NNUH).

METHODS

This is a single centre, prospective, observational cohort study of patients over the age of sixty admitted with a hip fracture to NNUH between March 24th and April 22nd, 2020 and comparing them retrospectively with controls in April 2019. Patients were followed up for 30 days; data collected includes demographics, COVID-19 PCR results, date/cause of death and other prognostic indicators.

RESULTS

66 consecutive patients managed for hip fractures were included in the study. 30-day mortality increased from 8.5% in April 2019 to 18.2% in April 2020. The 30-day mortality rate was 80% for those patients who test positive for COVID-19 as an inpatient, and was 13.8% for patients COVID-19 negative and for those who were untested. Those admitted from a healthcare institution were more likely to test positive for COVID-19 and had a higher 30-day mortality (p = 0.04 & p = 0.006, respectively). Suspected COVID-19-positive patients at time of admission had a delayed time to theatre, 46.7 h versus 27.1 h (p = 0.007), however this had no significant effect on mortality (p = 0.7).

CONCLUSIONS

The combination of fragility hip fracture and COVID-19 is associated with poor outcomes. COVID-19 has also indirectly increased mortality in this patient group.

摘要

引言

髋部骨折是英国老年人群中最常见的外伤性损伤。患者通常身体非常虚弱,合并多种合并症,因此如果感染 COVID-19,死亡风险很高。本研究旨在量化 COVID-19 对因髋部骨折到诺福克和诺维奇大学医院(NNUH)就诊的患者的影响。

方法

这是一项在 2020 年 3 月 24 日至 4 月 22 日期间,对因髋部骨折到 NNUH 就诊的年龄在 60 岁以上的患者进行的单中心、前瞻性、观察性队列研究,并与 2019 年 4 月的对照组进行回顾性比较。对患者进行 30 天的随访;收集的数据包括人口统计学、COVID-19 PCR 结果、死亡日期/原因和其他预后指标。

结果

66 例连续接受髋部骨折治疗的患者纳入研究。2019 年 4 月的 30 天死亡率为 8.5%,2020 年 4 月为 18.2%。住院期间 COVID-19 检测呈阳性的患者 30 天死亡率为 80%,COVID-19 检测阴性的患者和未检测的患者为 13.8%。从医疗机构入院的患者更有可能 COVID-19 检测呈阳性,30 天死亡率更高(p=0.04 和 p=0.006)。入院时疑似 COVID-19 阳性的患者手术时间延迟,为 46.7 小时对 27.1 小时(p=0.007),但这对死亡率没有显著影响(p=0.7)。

结论

脆性髋部骨折和 COVID-19 的结合与不良结局相关。COVID-19 也间接增加了这组患者的死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7d3/8008328/8f4967d96a5a/68_2021_1649_Fig1_HTML.jpg

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