Department of Oral and Maxillofacial and Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, 200011, People's Republic of China.
Eur Arch Otorhinolaryngol. 2022 Jan;279(1):391-398. doi: 10.1007/s00405-021-06786-6. Epub 2021 Mar 30.
The risk factors for the survival of elderly patients with oral squamous cell carcinoma (OSCC) are multifarious. Here, we developed a novel clinical signature to serve as an indicator of prognosis in these patients.
Clinicopathological data were collected for 554 patients aged ≥ 60 years who were treated for primary OSCC. Overall survival (OS), disease-specific survival, and disease-free survival were the primary outcomes.
Multivariate cox regression analysis showed that high N stage, low hemoglobin level, low body mass index (BMI), and high neutrophil-to-lymphocyte ratio (NLR) showed a poor survival (P < 0.05). A nomogram was constructed with a c-index of 0.702.
A novel clinical signature including hemoglobin level, BMI, and NLR, which are obtained through noninvasive examinations can be used as prognostic indicators in clinical practice for elderly patients with OSCC.
老年人口腔鳞状细胞癌（OSCC）患者的生存风险因素多种多样。在这里，我们开发了一种新的临床特征，作为这些患者预后的指标。
收集了 554 名年龄≥60 岁的原发性 OSCC 患者的临床病理数据。总生存期（OS）、疾病特异性生存期和无病生存期是主要观察终点。
多变量 Cox 回归分析显示，N 分期高、血红蛋白水平低、体重指数（BMI）低和中性粒细胞与淋巴细胞比值（NLR）高均与较差的生存相关（P<0.05）。构建了一个包含血红蛋白水平、BMI 和 NLR 的列线图，其 C 指数为 0.702。
一种新的临床特征，包括通过非侵入性检查获得的血红蛋白水平、BMI 和 NLR，可以作为老年 OSCC 患者临床实践中的预后指标。
