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The human liver-type pyruvate kinase (PKL) gene is on chromosome 1 at band q21.

作者信息

Satoh H, Tani K, Yoshida M C, Sasaki M, Miwa S, Fujii H

机构信息

Chromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo, Japan.

出版信息

Cytogenet Cell Genet. 1988;47(3):132-3. doi: 10.1159/000132530.

DOI:10.1159/000132530
PMID:3378452
Abstract

Pyruvate kinase (PK) is an important enzyme for ATP production in the glycolytic pathway. Deficiency of this enzyme in erythrocytes is characterized by hemolytic anemia. Using in situ hybridization, we have mapped the human liver-type pyruvate kinase gene (PKL) to band q21 of chromosome 1.

摘要

相似文献

1
The human liver-type pyruvate kinase (PKL) gene is on chromosome 1 at band q21.
Cytogenet Cell Genet. 1988;47(3):132-3. doi: 10.1159/000132530.
2
Pyruvate kinase deficiency.
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Human liver type pyruvate kinase: cDNA cloning and chromosomal assignment.人肝脏型丙酮酸激酶:cDNA克隆及染色体定位
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[From gene to disease; hereditary non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency].[从基因到疾病;丙酮酸激酶缺乏所致遗传性非球形红细胞溶血性贫血]
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[Pyruvate kinase (PK) isozyme switching and genetic heterogeneity of PK deficiency].[丙酮酸激酶(PK)同工酶转换与PK缺乏症的遗传异质性]
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Human platelet factor 4 gene is mapped to 4q12----q21.人类血小板因子4基因定位于4q12----q21。
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Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 deficiency in a family with hereditary spherocytosis.部分丙酮酸激酶缺乏症加重遗传性球形红细胞增多症一家系中 3 带缺乏的表型表达。
Am J Hematol. 2015 Mar;90(3):E35-9. doi: 10.1002/ajh.23899. Epub 2014 Nov 24.

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