Neuronal oscillations and the mouse prefrontal cortex.

The mouse prefrontal cortex (PFC) encompasses a collection of agranual brain regions in the rostral neocortex and is considered to be critically involved in the neuronal computations underlying intentional behaviors. Flexible behavioral responses demand coordinated integration of sensory inputs with state, goal and memory information in brain-wide neuronal networks. Neuronal oscillations are proposed to provide a temporal scaffold for coordination of neuronal network activity and routing of information. In the present book chapter, we review findings on the role neuronal oscillations in prefrontal functioning, with a specific focus on research in mice. We discuss discoveries pertaining to local prefrontal processing, as well to interactions with other brain regions. We also discuss how the recent discovery of brain-wide respiration-entrained rhythms (RR) warrant re-evaluation of certain findings on slow oscillations (<10Hz) in prefrontal functioning.