Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Shibei District, Qingdao, 266035, Shandong, China.
Department of Endocrinology and Metabolism, Zaozhuang Municipal Hospital, Zaozhuang, China.
Sci Rep. 2021 Mar 30;11(1):7215. doi: 10.1038/s41598-021-86677-2.
Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. This study is performed to evaluate the association between serum and aqueous humor myonectin concentrations with diabetic retinopathy (DR). This study was performed in a population of 228 patients with type 2 diabetes (T2DM) and 72 control subjects. Diabetic patients were then divided into T2DM patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients. Serum and aqueous humor myonectin concentrations were significantly lower in the case group than in the control group. PDR patients showed significantly decreased serum and aqueous humor myonectin concentrations than in the other two T2DM patients. In addition, NPDR patients showed significantly lower serum and aqueous humor myonectin concentrations than T2DM patients without DR. Logistic regression analysis demonstrated that serum and aqueous humor myonectin was correlated with a decreased risk of T2DM and DR. Simple linear regression analysis showed that serum myonectin was negatively correlated with duration of disease, body mass index (BMI), and HbA1c. Duration of disease and BMI were still correlated with the serum myonectin after a multiple linear regression analysis. Aqueous humor myonectin was negatively correlated with duration of disease, systolic blood pressure (SBP), and diastolic blood pressure. Duration of disease and SBP was still correlated with the aqueous humor myonectin after a multiple linear regression analysis. Our investigation indicates an inverse association of serum and aqueous humor myonectin with DR.
肌联蛋白是一种新发现的肌肉因子，可增强培养的脂肪细胞和肝细胞对脂肪酸的摄取，并抑制小鼠循环游离脂肪酸水平。本研究旨在评估血清和房水中肌联蛋白浓度与糖尿病视网膜病变（DR）的关系。该研究在 228 例 2 型糖尿病（T2DM）患者和 72 例对照者中进行。然后将糖尿病患者分为无 DR 的 T2DM 患者、非增生性糖尿病视网膜病变（NPDR）患者和增生性糖尿病视网膜病变（PDR）患者。与对照组相比，病例组血清和房水中肌联蛋白浓度显著降低。与其他两种 T2DM 患者相比，PDR 患者的血清和房水中肌联蛋白浓度明显降低。此外，NPDR 患者的血清和房水中肌联蛋白浓度明显低于无 DR 的 T2DM 患者。Logistic 回归分析表明，血清和房水中的肌联蛋白与 T2DM 和 DR 的风险降低相关。简单线性回归分析表明，血清肌联蛋白与疾病持续时间、体重指数（BMI）和糖化血红蛋白（HbA1c）呈负相关。在多元线性回归分析后，疾病持续时间和 BMI 与血清肌联蛋白仍相关。房水肌联蛋白与疾病持续时间、收缩压（SBP）和舒张压呈负相关。在多元线性回归分析后，疾病持续时间和 SBP 与房水肌联蛋白仍相关。我们的研究表明，血清和房水中的肌联蛋白与 DR 呈负相关。
