Li Zhu, Yang Yan-Ling, Zhu Yan-Juan, Li Chen-Guang, Tang Yun-Zhao, Ni Chang-Lin, Chen Li-Ming, Niu Wen-Yan
Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Exp Clin Endocrinol Diabetes. 2021 Jul;129(7):528-534. doi: 10.1055/a-0896-8548. Epub 2019 Jul 24.
Myonectin is one of the myokines and has gained interest as a potential new strategy to combat obesity and its associated disorders, such as type 2 diabetes mellitus (T2DM).The objective of this study was to investigate circulating serum myonectin levels in nondiabetes and T2DM and elucidate possible relationships between serum myonectin levels and metabolic parameters in patients with T2DM.
A total of 362 Chinese patients with T2DM and 100 age- and sex-matched healthy controls were recruited in this study. Clinical characteristics, blood biochemistry, and circulating myonectin levels were measured by enzyme-linked immunosorbent assay.
Circulating myonectin levels were significantly decreased in T2DM compared with controls. Obese nondiabetic controls had significantly lower serum myonectin levels compared with lean nondiabetic controls. In diabetic patients, serum myonectin concentrations were significantly negatively correlated with body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting insulin (Fins), the homeostatic model assessment of insulin resistance (HOMA-IR), visceral fat area, and subcutaneous fat area. After adjusting for covariates, multivariate stepwise regression analysis demonstrated that BMI, LDL-C, TG, HOMA-IR, and visceral fat were the main independent predictors of low serum myonectin concentrations.
Circulating myonectin levels were decreased in T2DM patients and in obese subjects. Moreover, serum myonectin levels were correlated with metabolic markers of T2DM. These data suggest that myonectin may be a useful marker in predicting the development of obesity and T2DM.
肌连接蛋白是一种肌动蛋白，作为对抗肥胖及其相关疾病（如2型糖尿病（T2DM））的潜在新策略已引起关注。本研究的目的是调查非糖尿病患者和T2DM患者循环血清中肌连接蛋白水平，并阐明T2DM患者血清肌连接蛋白水平与代谢参数之间的可能关系。
本研究共招募了362名中国T2DM患者和100名年龄及性别匹配的健康对照者。通过酶联免疫吸附测定法测量临床特征、血液生化指标和循环肌连接蛋白水平。
与对照组相比，T2DM患者的循环肌连接蛋白水平显著降低。肥胖的非糖尿病对照者血清肌连接蛋白水平显著低于瘦的非糖尿病对照者。在糖尿病患者中，血清肌连接蛋白浓度与体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、C反应蛋白（CRP）、糖化血红蛋白（HbA1c）、空腹胰岛素（Fins）、胰岛素抵抗稳态模型评估（HOMA-IR）、内脏脂肪面积和皮下脂肪面积显著负相关。在调整协变量后，多因素逐步回归分析表明，BMI、LDL-C、TG、HOMA-IR和内脏脂肪是血清肌连接蛋白浓度低的主要独立预测因素。
T2DM患者和肥胖受试者循环肌连接蛋白水平降低。此外，血清肌连接蛋白水平与T2DM的代谢标志物相关。这些数据表明，肌连接蛋白可能是预测肥胖和T2DM发生发展的有用标志物。
